INT130167

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv1) intracellular (Calca) cytoplasm (Calca)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1) cytosol (Trpv1)
Anatomy Link Frequency
trachea 2
nociceptors 2
Trpv1 (Mus musculus)
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
nociceptor 3 100.00 Very High Very High Very High
Inflammation 4 99.28 Very High Very High Very High
bradykinin 2 99.12 Very High Very High Very High
qutenza 4 92.32 High High
Neuropeptide 1 88.40 High High
c fibre 2 71.48 Quite High
agonist 3 64.92 Quite High
antagonist 1 59.12 Quite High
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 2 99.72 Very High Very High Very High
Cough 2 97.12 Very High Very High Very High
INFLAMMATION 2 96.36 Very High Very High Very High
Hypersensitivity 2 95.84 Very High Very High Very High
Targeted Disruption 2 78.52 Quite High
Nociception 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results further suggest that TRPV1 is not responsible for the normal heat response of native nociceptors but plays the essential role in thermal sensitization and a prominent one in controlling dermal calcitonin gene-related peptide release, i.e. neurogenic inflammation.
TRPV1 Regulation (controlling) of Localization (release) of calcitonin in nociceptors associated with inflammation, nociceptor, neurogenic inflammation and calcitonin gene-related peptide
1) Confidence 0.38 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165301 Disease Relevance 0.17 Pain Relevance 0.45
TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea.
TRPV1 Regulation (controls) of Localization (release) of calcitonin in trachea associated with bradykinin and calcitonin gene-related peptide
2) Confidence 0.29 Published 2009 Journal Eur. J. Neurosci. Section Title Doc Link 19473241 Disease Relevance 0.52 Pain Relevance 0.58

General Comments

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