INT130176

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Context Info
Confidence 0.66
First Reported 1999
Last Reported 2011
Negated 6
Speculated 4
Reported most in Body
Documents 125
Total Number 129
Disease Relevance 137.06
Pain Relevance 25.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 20
blood 12
body 10
heart 8
liver 8
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2315 100.00 Very High Very High Very High
cytokine 738 100.00 Very High Very High Very High
rheumatoid arthritis 518 99.58 Very High Very High Very High
Angina 317 99.36 Very High Very High Very High
Inflammatory response 169 99.34 Very High Very High Very High
backache 2 99.30 Very High Very High Very High
Inflammatory marker 197 99.20 Very High Very High Very High
Infliximab 310 99.12 Very High Very High Very High
anesthesia 21 99.00 Very High Very High Very High
Adalimumab 248 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2664 100.00 Very High Very High Very High
Disease 1483 100.00 Very High Very High Very High
Cv Unclassified Under Development 1092 100.00 Very High Very High Very High
Diabetes Mellitus 1003 100.00 Very High Very High Very High
Cancer 615 100.00 Very High Very High Very High
Coronary Artery Disease 350 100.00 Very High Very High Very High
Colon Cancer 227 100.00 Very High Very High Very High
Thyroiditis 220 100.00 Very High Very High Very High
Necrosis 202 100.00 Very High Very High Very High
Pathologic Dilatation 200 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, a large prospective study has shown that variants in the CRP gene are associated with marked increase of CRP levels, but these polymorphisms were not associated with increased risk of vascular disease [44].
Positive_regulation (increase) of Gene_expression (levels) of CRP associated with increased venous pressure under development
1) Confidence 0.66 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 1.39 Pain Relevance 0.09
One reason for this may be that elevated levels of C-reactive protein (CRP), which inhibits leptin's role in controlling appetite [13].
Positive_regulation (elevated) of Gene_expression (levels) of C-reactive protein
2) Confidence 0.59 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.86 Pain Relevance 0.08
Another experiment showed that human liver cells increased CRP expression when exposed to leptin, which suggests that appetite may be regulated through a feedback loop that includes the liver in addition to the brain and leptin-secreting fat cells [16].
Positive_regulation (increased) of Gene_expression (expression) of CRP in liver associated with obesity
3) Confidence 0.59 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.48 Pain Relevance 0.03
For example, IL-6 initiates the acute-phase response inducing the hepatic synthesis of acute phase proteins including C-reactive protein (CRP), serum amyloid, haptoglobin, and fibrinogen among others (Cronstein 2007).
Positive_regulation (inducing) of Gene_expression (synthesis) of CRP associated with alzheimer's dementia
4) Confidence 0.50 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 1.17 Pain Relevance 0.41
Since heritable units are randomly assigned at conception, genotypes within them should not be associated with confounding factors, such as smoking and socioeconomic circumstances, nor will the genotype be affected by disease processes that influence CRP levels.[8]–[10] Thus, the association between a genotype that is associated with circulating CRP levels and CHD provides a robust test of whether circulating CRP is causally related to CHD.
Positive_regulation (circulating) of Gene_expression (levels) of CRP associated with nicotine addiction, cv unclassified under development and disease
5) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.91 Pain Relevance 0
All analyses were conducted only on those with complete data for genotype, CRP levels and CHD (see table 1 for numbers).
Positive_regulation (conducted) of Gene_expression (levels) of CRP associated with cv unclassified under development
6) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.39 Pain Relevance 0
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (prevalent) of Gene_expression (levels) of CRP associated with cv unclassified under development
7) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.08 Pain Relevance 0
The pooled odds ratio of CHD per doubling of circulating CRP level after adjustment for age and sex was 1.13 (95%CI: 1.06, 1.21), and after further adjustment for confounding factors it was 1.07 (95%CI: 1.02, 1.13).
Positive_regulation (circulating) of Gene_expression (level) of CRP associated with cv unclassified under development
8) Confidence 0.50 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.65 Pain Relevance 0
We estimated the association of CRP genetic variant +1444C>T (rs1130864) with CRP levels and with CHD in five studies and then pooled these analyses (N?
Positive_regulation (with) of Gene_expression (levels) of CRP associated with cv unclassified under development
9) Confidence 0.50 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.68 Pain Relevance 0
We estimated the association of CRP genetic variant +1444C>T (rs1130864) with CRP levels and with CHD in five studies and then pooled these analyses (N?
Positive_regulation (with) of Gene_expression (levels) of CRP associated with cv unclassified under development
10) Confidence 0.50 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.68 Pain Relevance 0
Associations were of a similar magnitude for prevalent CHD (CRP levels measured at same time as history of CHD ascertained) and incident CHD (CRP levels measured before new cases of CHD) in each cohort, and with a combined outcome of prevalent and incident CHD.
Positive_regulation (incident) of Gene_expression (levels) of CRP associated with cv unclassified under development
11) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.07 Pain Relevance 0
METHODS: In 105 consecutive patients with UA, we assessed the CRP 1059G/C polymorphism, CRP plasma levels and interleukin-6 production after in-vitro stimulation of whole blood with lipopolysaccharide (1 ng/ml).
Positive_regulation (assessed) of Gene_expression (production) of CRP in blood
12) Confidence 0.50 Published 2007 Journal Coron. Artery Dis. Section Body Doc Link 17925606 Disease Relevance 0 Pain Relevance 0
In conclusion, CRP levels estimated in saliva of SAT patients were observed to be significantly increased compared to HT patients and euthyroid controls in our study.
Positive_regulation (increased) of Gene_expression (levels) of CRP in saliva associated with thyroiditis
13) Confidence 0.50 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.31 Pain Relevance 0.23
Determinants of C-reactive protein
Positive_regulation (Determinants) of Spec (Determinants) Gene_expression (Determinants) of C-reactive protein
14) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246234 Disease Relevance 1.31 Pain Relevance 0.48
The most intense CRP expression was observed during the accelerated inflammatory phase.
Positive_regulation (intense) of Gene_expression (expression) of CRP associated with inflammation
15) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.20 Pain Relevance 0.20
Our study found CRP expression in early obliterative plugs, but not in the mature, scar-like lesions, in which the existence of ?
Neg (not) Positive_regulation (found) of Gene_expression (expression) of CRP in plugs associated with cicatrix
16) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.97 Pain Relevance 0.22
Of note, statin therapy proved to be effective in reducing risk for first coronary events in subjects with elevated CRP levels in the absence of overt hyperlipaemia (

Ridker and others, 2001b

).

Positive_regulation (elevated) of Gene_expression (levels) of CRP
17) Confidence 0.49 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.28 Pain Relevance 0.07
A CRP response indicated stable disease or objective response in most patients; however, few patients experienced progressive disease (6%) despite of a CRP response.
Positive_regulation (experienced) of Gene_expression (response) of CRP associated with disease
18) Confidence 0.49 Published 2008 Journal Cancer Microenviron Section Body Doc Link PMC2654356 Disease Relevance 2.32 Pain Relevance 0.31
It induces the synthesis of CRP and acid ?
Positive_regulation (induces) of Gene_expression (synthesis) of CRP
19) Confidence 0.49 Published 2006 Journal BMC Surg Section Body Doc Link PMC1712352 Disease Relevance 0.86 Pain Relevance 0.12
aneurysm, and higher serum CRP levels were observed in
Positive_regulation (higher) of Gene_expression (levels) of CRP associated with aneurism
20) Confidence 0.49 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804298 Disease Relevance 1.76 Pain Relevance 0.33

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