INT130186

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Context Info
Confidence 0.74
First Reported 2004
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 101
Total Number 108
Disease Relevance 79.96
Pain Relevance 25.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
brain 15
lung 6
leukocyte 6
plasma 3
cerebellum 2
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2804 100.00 Very High Very High Very High
cytokine 1141 100.00 Very High Very High Very High
Central nervous system 793 99.68 Very High Very High Very High
Inflammation 2102 99.44 Very High Very High Very High
b2 receptor 136 99.38 Very High Very High Very High
imagery 58 98.92 Very High Very High Very High
ischemia 87 98.80 Very High Very High Very High
Multiple sclerosis 833 98.12 Very High Very High Very High
corticosteroid 106 96.68 Very High Very High Very High
opiate 36 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chlamydia Infection 975 100.00 Very High Very High Very High
Cancer 248 100.00 Very High Very High Very High
Necrosis 129 100.00 Very High Very High Very High
Multiple Sclerosis 1636 99.92 Very High Very High Very High
Disease 792 99.92 Very High Very High Very High
Infection 2077 99.86 Very High Very High Very High
Endometriosis 131 99.84 Very High Very High Very High
Central Nervous System Disease 576 99.68 Very High Very High Very High
Malaria 1536 99.66 Very High Very High Very High
Cerebral Malaria 1250 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Gene_expression (expression) of Ccl5 in retinas
1) Confidence 0.74 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35
In particular, the In1.1T/C haplotype of ccl5 is highly prevalent (~37%) in African Americans, than compared to Americans of European origin (~0.3%), and results in significantly lower CCL5 expression [48].
Gene_expression (expression) of CCL5
2) Confidence 0.72 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.00 Pain Relevance 0.11
Murine anti-CCL5 was produced as previously described [34].
Gene_expression (produced) of CCL5
3) Confidence 0.72 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.52 Pain Relevance 0.11
The expression of RANTES and CCR5 mRNA in P. yoelii 17XL-infected mouse brain in this study suggests a Th1-mediated immune response, and that factors capable of inducing Th1 response could play an important role in modulating malaria infections.
Gene_expression (expression) of RANTES in brain associated with malaria and infection
4) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.65 Pain Relevance 0.32
Systemic increase in RANTES protein expression began four days after P. yoelii 17XL infection, until peak parasitaemia at day eight with about three-fold upregulation in infected plasma compared with control [Figure 4B].


Gene_expression (expression) of RANTES in plasma associated with infection
5) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.47 Pain Relevance 0.03
Western blot analysis was used to confirm RANTES protein expression in mouse brain during P. yoelii 17XL infection.
Gene_expression (expression) of RANTES in brain associated with infection
6) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.10 Pain Relevance 0
Expression of RANTES protein in brain tissues followed a similar profile consistent with mRNA expression indicating that RANTES mRNA expression in brains of P. yoelii 17XL infected mice were translated into protein.
Gene_expression (Expression) of RANTES in brains
7) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.62 Pain Relevance 0
Plasma samples from infected mice at each time point as well as uninfected controls were assayed for RANTES protein expression.
Gene_expression (expression) of RANTES in Plasma
8) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.47 Pain Relevance 0.03
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Gene_expression (expression) of RANTES in brain associated with malaria and infection
9) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.76 Pain Relevance 0.20
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Gene_expression (expressions) of RANTES in brains associated with chemokine
10) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.49 Pain Relevance 0.40
RANTES protein expression was normalized to that of alpha-tubulin.


Gene_expression (expression) of RANTES
11) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.06 Pain Relevance 0.05
Expression of chemoattractants Ccl5 and Ccl8, which promote monocyte and lymphocyte recruitment [106,107], is consistent with the presence of B cells and the dominance of immunoglobulin genes and the perivascular and brain parenchymal inflammatory process.
Gene_expression (Expression) of Ccl5 in B cells associated with inflammation
12) Confidence 0.66 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.26 Pain Relevance 0.07
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
Gene_expression (expressed) of CCL5 associated with chemokine and chlamydia infection
13) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.61 Pain Relevance 0.16
CCR5, but not CCL5 or IFN-?
Neg (not) Gene_expression (not) of CCL5
14) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.19 Pain Relevance 0.11
The results in the present study suggest that CCL5 is required for optimal Th1 cellular responses against and clearance of Chlamydia.
Gene_expression (required) of CCL5 associated with chlamydia infection
15) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.75 Pain Relevance 0.17
Anti-CCL5 antibody production
Gene_expression (production) of CCL5
16) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.58 Pain Relevance 0.11
Previously, we demonstrated that CCL5 inhibition decreased the numbers of NK1.1+ and CD11b+ leukocytes at mucosal effector sites following pneumococcal challenge [34].
Neg (inhibition) Gene_expression (inhibition) of CCL5 in leukocytes
17) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.50 Pain Relevance 0.07
These results indicate that C. muridarum infection invoked splenic, but not ILNs, Chlamydia-specific CD4+ T cells that secreted Th1 cytokines as well as IL-6, IL-10, and GM-CSF, which were reduced by CCL5 blockade.
Gene_expression (blockade) of CCL5 in T cells associated with chlamydia infection, infection and cytokine
18) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.52 Pain Relevance 0.15
The present study shows that 7 days after genital Chlamydia infection, CCL5, CCR5, and IFN?
Gene_expression (shows) of CCL5 associated with chlamydia infection
19) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.80 Pain Relevance 0.18
In addition, the production of CCL5 was lower in B2-/- mice when compared to their WT controls subjected to EAE (Figure 4B).
Gene_expression (production) of CCL5 associated with multiple sclerosis
20) Confidence 0.61 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.11 Pain Relevance 0.31

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