INT130188

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
plasma 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 5 99.60 Very High Very High Very High
cINOD 5 98.88 Very High Very High Very High
diclofenac 1 97.28 Very High Very High Very High
Inflammation 1 83.36 Quite High
antagonist 1 75.60 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 29 99.98 Very High Very High Very High
Necrosis 2 98.54 Very High Very High Very High
Cancer 1 98.36 Very High Very High Very High
Diabetes Mellitus 10 97.84 Very High Very High Very High
Peptic Ulcer 1 97.72 Very High Very High Very High
Hepatotoxicity 3 90.28 High High
Hyperglycemia 1 89.28 High High
Drug-induced Liver Injury 4 86.24 High High
Poisoning 2 85.68 High High
INFLAMMATION 2 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rats intoxicated with acetaminophen showed significant elevation in the levels of lipid peroxides with decreased levels of protein, GSH, SOD, CAT and impaired tricarboxylic acid cycle enzyme activities.
Positive_regulation (elevation) of Negative_regulation (decreased) of CAT associated with paracetamol
1) Confidence 0.45 Published 2005 Journal Chemosphere Section Abstract Doc Link 16168751 Disease Relevance 0.24 Pain Relevance 0.34
CCl4-induced generation of peroxy radicals and O2-• leads to inactivation of catalase and SOD.
Positive_regulation (leads) of Negative_regulation (inactivation) of catalase
2) Confidence 0.37 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
Indomethacin treatment led to an increase in lipid peroxidation, glutathione peroxidase and glucose-6-phosphate dehydrogenase activities and to a decrease in catalase activity and glutathione levels in gastric mucosa.
Positive_regulation (led) of Negative_regulation (decrease) of catalase
3) Confidence 0.33 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391279 Disease Relevance 0.08 Pain Relevance 0.43
Although, compare to control group, the catalase activity of vitamin B6 deficient group was significantly lower regardless of exercise, this difference was decreased in post-exercise and recess after exercise because exercise-induced oxidative stress induced the decrease of plasma catalase activity in control group but exercise-induced oxidative stress did not affect the catalase activity in vitamin B6 deficient group.
Positive_regulation (induced) of Negative_regulation (decrease) of catalase in plasma associated with stress
4) Confidence 0.32 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.41 Pain Relevance 0
Also, telmisartan significantly reduced the elevations of total gastric acid output, pepsin activity, gastric ulcer index and gastric mucosal tumor necrosis factor-alpha, nitric oxide, malondialdehyde and caspase-3 activity, and restored the depleted antioxidant defenses (reduced glutathione level, and superoxide dismutase and catalase activities) caused by indomethacin administration in diabetic rats.
Positive_regulation (restored) of Negative_regulation (reduced) of catalase associated with necrosis, diabetes mellitus, cancer and peptic ulcer
5) Confidence 0.25 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20399771 Disease Relevance 0.96 Pain Relevance 0.09

General Comments

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