INT130199

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.89
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
plasma 2
leukocytes 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cOX1 20 100.00 Very High Very High Very High
cINOD 186 99.98 Very High Very High Very High
Inflammation 200 81.12 Quite High
acular 48 77.44 Quite High
diclofenac 26 77.00 Quite High
Analgesic 4 73.52 Quite High
rheumatoid arthritis 12 65.20 Quite High
Pain 31 62.88 Quite High
Inflammatory mediators 8 62.16 Quite High
Inflammatory stimuli 5 58.16 Quite High
Disease Link Frequency Relevance Heat
Disease 28 99.04 Very High Very High Very High
INFLAMMATION 225 95.88 Very High Very High Very High
Drug Induced Neurotoxicity 3 75.00 Quite High
Alzheimer's Dementia 2 75.00 Quite High
Neuroblastoma 2 75.00 Quite High
Rheumatoid Arthritis 12 65.20 Quite High
Pain 31 62.88 Quite High
Cataract 36 62.28 Quite High
Otitis 1 60.40 Quite High
Hypoxia 12 46.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although most NSAIDs inhibit the activity of cyclooxygenase (COX), the rate-limiting enzyme in the production of prostanoids from arachidonic acid (AA), the precise mechanism through which NSAIDs act upon AD pathology remains to be elucidated.
Negative_regulation (inhibit) of COX Neg (inhibit) Binding (activity) of associated with cinod and disease
1) Confidence 0.30 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 0.75 Pain Relevance 0.47
Nepafenac as a parent compound exhibits weak intrinsic COX inhibitory activity (COX1 inhibitory activity IC50 64.3 ?
Negative_regulation (inhibitory) of COX Binding (activity) of associated with cox1
2) Confidence 0.10 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.37 Pain Relevance 0.67
Nepafenac as a parent compound exhibits weak intrinsic COX inhibitory activity (COX1 inhibitory activity IC50 64.3 ?
Negative_regulation (inhibitory) of COX Binding (activity) of associated with cox1
3) Confidence 0.10 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.37 Pain Relevance 0.67
We also show here for the first time that after oral ingestion of PFE, constituents of PFE or their metabolites that become bioavailable in plasma significantly inhibited the activity of COX-1 and COX-2 enzymes in a direct enzyme inhibition assay with the inhibitory effect being targeted more towards COX-2.
Negative_regulation (inhibited) of COX Binding (activity) of in plasma
4) Confidence 0.08 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2438359 Disease Relevance 0.18 Pain Relevance 0.09
For instance, Landolfi et al. found that flavone, chrysin, apigenein, and phloretin depressed COX activity and inhibited platelet aggregation.16 The flavonoids, 6-hydroxykaempferol, and quercetagenin isolated from T. parthenium (feverfew), and 6-hydroxyluteolin and scutellarein isolated from T. vulgaris (tansy) were shown to inhibit COX activity in leukocytes.17 The triterpenes sasanquol isolated from C. sasanqua (Theaceae) and 3?
Negative_regulation (depressed) of COX Binding (activity) of in leukocytes
5) Confidence 0.04 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.22 Pain Relevance 0.21

General Comments

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