INT130202

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.89
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
microglia 4
neuron 2
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 2 100.00 Very High Very High Very High
Neuropathic pain 14 99.76 Very High Very High Very High
cytokine 10 93.52 High High
Pain 16 92.88 High High
Migraine 1 83.88 Quite High
Dorsal horn 2 83.84 Quite High
IPN 1 82.92 Quite High
adenocard 3 82.72 Quite High
Central nervous system 8 71.04 Quite High
Spinal cord 2 69.52 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 100.00 Very High Very High Very High
Neuropathic Pain 17 99.76 Very High Very High Very High
Pain 9 91.08 High High
Infection 4 89.44 High High
Diabetes Mellitus 2 88.88 High High
Cancer 2 87.60 High High
Necrosis 2 87.12 High High
Headache 1 83.88 Quite High
Inflammatory Pain 1 82.92 Quite High
Injury 4 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also provide new original data showing a time-dependent downregulation of P2Y2 and P2Y4 receptor expression and function in purified SGCs cultures from TG, in comparison with primary mixed neuron-SGCs cultures.
Negative_regulation (downregulation) of Gene_expression (expression) of P2Y4 receptor in neuron
1) Confidence 0.15 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20604978 Disease Relevance 0.56 Pain Relevance 0.57
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Negative_regulation (blocking) of Gene_expression (expression) of P2X4 receptor in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
2) Confidence 0.00 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.66 Pain Relevance 1.28
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Negative_regulation (suppressing) of Gene_expression (expression) of P2X4 receptor in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
3) Confidence 0.00 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.68 Pain Relevance 1.29

General Comments

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