INT130203

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.79
Pain Relevance 4.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
neurons 2
endothelium 2
P19 1
soma 1
microglia 1
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 13 99.84 Very High Very High Very High
Neuropathic pain 11 99.76 Very High Very High Very High
Inflammation 132 99.68 Very High Very High Very High
antagonist 146 98.26 Very High Very High Very High
Peripheral nerve injury 2 97.32 Very High Very High Very High
Serotonin 2 96.32 Very High Very High Very High
Inflammatory response 10 93.76 High High
Pain 41 92.88 High High
nociceptor 44 92.40 High High
Somatostatin 1 91.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 14 99.84 Very High Very High Very High
Neuropathic Pain 18 99.76 Very High Very High Very High
Infection 3 99.76 Very High Very High Very High
INFLAMMATION 127 99.68 Very High Very High Very High
Diabetes Mellitus 36 99.24 Very High Very High Very High
Lung Injury 29 98.86 Very High Very High Very High
Cancer 12 98.84 Very High Very High Very High
Pressure And Volume Under Development 12 98.76 Very High Very High Very High
Stress 60 97.96 Very High Very High Very High
Nociception 18 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To define the role played by extracellular ATP in the pathogenesis of lung inflammation due to mechanical ventilation, we 1) examined the effects of ATP exogenously instilled in the airways, 2) measured the concentrations of extracellular ATP in broncho-alveolar lavage (BAL) fluid after mechanical ventilation, 3) determined whether a purinergic receptor antagonist can alleviate the lung injury caused by mechanical ventilation, and 4) documented the expression of the P2Y2 and P2Y4 ATP receptors in lung tissue.
Gene_expression (expression) of P2Y4 in lung associated with lung injury, inflammation, antagonist and pneumonia
1) Confidence 0.50 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.68 Pain Relevance 0.47
Four P2Y receptor subtypes (P2Y1, P2Y2, P2Y4 and P2Y6) have been detected in DRG neurones (Gerevich & Illes, 2004), but their role in nociception has only just begun to be investigated (Gerevich & Illes, 2004; Malin et al. 2008).
Gene_expression (detected) of P2Y4 associated with nociception and dorsal root ganglion
2) Confidence 0.28 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.85 Pain Relevance 0.68
Differential expression and activity of P2Y1, P2Y2, P2Y4, P2X2 subtypes and P2X6 subunits were reported during neuronal maturation of P19 cells [38, 39].
Gene_expression (expression) of P2Y4 in P19
3) Confidence 0.26 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.27 Pain Relevance 0.11
P2Y2 and P2Y4 receptors were profusely expressed in astrocytes but no immunofluorescence was seen in neurons (Fig. 4, A and B).
Gene_expression (expressed) of P2Y4 in neurons
4) Confidence 0.23 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0
However in the hippocampal cultures we did not find P2Y2 or P2Y4 immunostaining either in neuronal soma or the synaptic release sites identified by synaptophysin labeling (Figs. 3 and 4).
Spec (find) Gene_expression (immunostaining) of P2Y4 in soma
5) Confidence 0.23 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.15
We also provide new original data showing a time-dependent downregulation of P2Y2 and P2Y4 receptor expression and function in purified SGCs cultures from TG, in comparison with primary mixed neuron-SGCs cultures.
Gene_expression (expression) of P2Y4 receptor in neuron
6) Confidence 0.19 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20604978 Disease Relevance 0.55 Pain Relevance 0.56
As mentioned above, the P2X4 receptor is the most abundantly expressed P2 receptor in the endothelium and mediates shear stress-stimulated vasodilatation.
Gene_expression (expressed) of P2X4 receptor in endothelium associated with stress and increased venous pressure under development
7) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.11 Pain Relevance 0.09
The P2Y2 receptor is the most abundantly expressed receptor with very low levels of the P2Y4 receptor in the human heart [161], suggesting that the inotropic effects of UTP are mediated via P2Y2 receptors, while the UDP effects are mediated via the P2Y6 receptor [161].
Gene_expression (expressed) of P2Y4 receptor in heart
8) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.13 Pain Relevance 0.17
The first P2Y receptor to be cloned [2], thus named P2Y1, is an ADP receptor expressed in a wide range of tissues which activates PLC?
Gene_expression (expressed) of P2Y receptor
9) Confidence 0.07 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.31 Pain Relevance 0.15
The P2X1 receptor is not expressed on the vascular endothelium and the evidence for other P2X receptors has been scarce, except for the P2X4 receptor which is the highest expressed P2 receptor in endothelium [40, 54].
Gene_expression (expressed) of P2X4 receptor in endothelium
10) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.63 Pain Relevance 0.03
Both types of mediators accumulate at the sites of inflammation, and inflammatory cells often co-express both P2Y and CysLT receptors [6].
Gene_expression (express) of P2Y associated with inflammation
11) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 1.25 Pain Relevance 0.23
Purinergic P2Y4 receptor was expressed in guinea pig ICC-IM, ICC-DMP and ICC-MY [46].
Gene_expression (expressed) of Purinergic P2Y4 receptor
12) Confidence 0.03 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1779949 Disease Relevance 0 Pain Relevance 0.29
There are multiple P2X and P2Y receptor subtypes expressed by monocytes and dendritic cells, whereas lymphocytes express only P2Y receptors [2].
Gene_expression (expressed) of P2Y receptor in lymphocytes
13) Confidence 0.02 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.32 Pain Relevance 0.13
The expression of the P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia in a peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produces a reduction of the neuropathic pain.
Gene_expression (expression) of P2X4 receptor in spinal associated with nervous system injury, neuropathic pain and peripheral nerve injury
14) Confidence 0.00 Published 2006 Journal Novartis Found. Symp. Section Abstract Doc Link 16805436 Disease Relevance 1.14 Pain Relevance 0.62
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Gene_expression (expression) of P2X4 receptor in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
15) Confidence 0.00 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.55 Pain Relevance 1.14

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