INT130204

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.73
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
spinal 2
microglia 2
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 11 99.76 Very High Very High Very High
Peripheral nerve injury 2 98.96 Very High Very High Very High
Pain 9 92.88 High High
cytokine 9 87.12 High High
adenocard 1 82.72 Quite High
Dorsal horn 2 78.08 Quite High
Inflammation 1 65.56 Quite High
ischemia 1 65.00 Quite High
Central nervous system 4 63.88 Quite High
Spinal cord 1 61.20 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 99.76 Very High Very High Very High
Infection 3 99.76 Very High Very High Very High
Diabetes Mellitus 2 99.24 Very High Very High Very High
Cancer 3 98.84 Very High Very High Very High
Nervous System Injury 5 98.52 Very High Very High Very High
Pain 4 90.20 High High
Necrosis 2 81.28 Quite High
Injury 3 70.08 Quite High
INFLAMMATION 1 65.56 Quite High
Cv Unclassified Under Development 1 65.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia in a peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produces a reduction of the neuropathic pain.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X4 receptor in spinal associated with nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.00 Published 2006 Journal Novartis Found. Symp. Section Abstract Doc Link 16805436 Disease Relevance 1.16 Pain Relevance 0.63
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X4 receptor in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
2) Confidence 0.00 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.57 Pain Relevance 1.15

General Comments

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