INT130208

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.07
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
nucleus 2
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 303 98.72 Very High Very High Very High
Inflammation 64 96.12 Very High Very High Very High
aspirin 13 85.08 High High
cytokine 49 77.48 Quite High
cINOD 3 66.08 Quite High
dexamethasone 14 63.88 Quite High
corticosteroid 16 63.32 Quite High
Inflammatory response 3 62.24 Quite High
psoriasis 22 39.12 Quite Low
Glutamate 1 34.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 75 96.12 Very High Very High Very High
Pulmonary Disease 32 88.00 High High
Cancer 9 87.68 High High
Necrosis 7 87.12 High High
Colon Cancer 5 84.36 Quite High
Apoptosis 1 83.36 Quite High
Asthma 24 82.88 Quite High
Airway Remodeling 10 75.48 Quite High
Toxicity 2 71.52 Quite High
Dermatitis 31 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
p-c-Jun, phosphorylated c-Jun
Positive_regulation (-) of Phosphorylation (phosphorylated) of p-c-Jun
1) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 1.00 Pain Relevance 0.65
The shift of redox balance towards oxidative conditions facilitates phosphorylation and activation of c-Jun N-terminal kinase (JNK), a kinase that promotes Jun translocation into the nucleus.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of c-Jun in nucleus
2) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.60 Pain Relevance 0.14
p-c-Jun, phosphorylated c-Jun
Positive_regulation (-) of Phosphorylation (phosphorylated) of Jun
3) Confidence 0.33 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0.94 Pain Relevance 0.63
The activation of JNK and p38 was accompanied by large increases in the phosphorylation of the downstream transcription factors cJun and activating transcription factor 2 (ATF-2).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of cJun
4) Confidence 0.07 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.52 Pain Relevance 0.50

General Comments

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