INT130209

Context Info Confidence 0.36 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.15 Pain Relevance 1.03

nucleoplasm (ATF2) nucleolus (ATF2) nucleus (ATF2) intracellular (ATF2) DNA binding (ATF2)

Anatomy Link Frequency ASK 2 ATF2 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 26 85.08 cINOD 2 66.08 Kinase C 1 60.16 Inflammation 48 5.00 cytokine 21 5.00 fibrosis 19 5.00 Inflammatory response 11 5.00 chemokine 6 5.00 alcohol 5 5.00 Bile 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 55 97.26 Colon Cancer 10 84.36 Cancer 5 75.52 Toxicity 4 71.52 INFLAMMATION 59 65.84 Wound Healing 12 50.00 Hypoxia 1 35.24 Stress 107 5.00 Death 55 5.00 Injury 46 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The activation of JNK and p38 was accompanied by large increases in the phosphorylation of the downstream transcription factors cJun and activating transcription factor 2 (ATF-2).

Positive_regulation (increases) of Phosphorylation (phosphorylation) of activating transcription factor 2

1) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.53 Pain Relevance 0.50

The activation of JNK and p38 was accompanied by large increases in the phosphorylation of the downstream transcription factors cJun and activating transcription factor 2 (ATF-2).

Positive_regulation (increases) of Phosphorylation (phosphorylation) of ATF-2

2) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.53 Pain Relevance 0.50

A peculiar mechanism is the one disclosed in studies designed to analyze ASK-1 (apoptosis signalling-regulating kinase 1) activation, which, in turn, leads to activation of MKK3/6, MKK4/MKK7 and then JNKs and p38MAPK, finally leading to phosphorylation of ATF-2, c-Jun and p53.

Positive_regulation (leading) of Phosphorylation (phosphorylation) of ATF-2 in ASK associated with apoptosis

3) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

This test has worked.