INT130209

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF2) nucleolus (ATF2) nucleus (ATF2)
intracellular (ATF2) DNA binding (ATF2)
Anatomy Link Frequency
ASK 2
ATF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 26 85.08 High High
cINOD 2 66.08 Quite High
Kinase C 1 60.16 Quite High
Inflammation 48 5.00 Very Low Very Low Very Low
cytokine 21 5.00 Very Low Very Low Very Low
fibrosis 19 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 55 97.26 Very High Very High Very High
Colon Cancer 10 84.36 Quite High
Cancer 5 75.52 Quite High
Toxicity 4 71.52 Quite High
INFLAMMATION 59 65.84 Quite High
Wound Healing 12 50.00 Quite Low
Hypoxia 1 35.24 Quite Low
Stress 107 5.00 Very Low Very Low Very Low
Death 55 5.00 Very Low Very Low Very Low
Injury 46 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of JNK and p38 was accompanied by large increases in the phosphorylation of the downstream transcription factors cJun and activating transcription factor 2 (ATF-2).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of activating transcription factor 2
1) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.53 Pain Relevance 0.50
The activation of JNK and p38 was accompanied by large increases in the phosphorylation of the downstream transcription factors cJun and activating transcription factor 2 (ATF-2).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of ATF-2
2) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.53 Pain Relevance 0.50
A peculiar mechanism is the one disclosed in studies designed to analyze ASK-1 (apoptosis signalling-regulating kinase 1) activation, which, in turn, leads to activation of MKK3/6, MKK4/MKK7 and then JNKs and p38MAPK, finally leading to phosphorylation of ATF-2, c-Jun and p53.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of ATF-2 in ASK associated with apoptosis
3) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.10 Pain Relevance 0.03

General Comments

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