INT130226

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 15.75
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
plasma 2
intestine 2
neutrophil 2
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 8 99.68 Very High Very High Very High
chemokine 18 99.36 Very High Very High Very High
Neuritis 6 99.36 Very High Very High Very High
rheumatoid arthritis 8 98.62 Very High Very High Very High
Inflammation 197 97.40 Very High Very High Very High
cytokine 74 92.64 High High
Central nervous system 22 75.56 Quite High
cva 8 68.96 Quite High
Inflammatory response 26 32.56 Quite Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 64 100.00 Very High Very High Very High
Intestinal Cancer 8 99.96 Very High Very High Very High
Cancer 330 99.84 Very High Very High Very High
Syndrome 8 99.84 Very High Very High Very High
Cystic Fibrosis 8 99.68 Very High Very High Very High
Experimental Autoimmune Neuritis 6 99.36 Very High Very High Very High
Infection 122 98.88 Very High Very High Very High
Rheumatoid Arthritis 8 98.62 Very High Very High Very High
INFLAMMATION 231 97.40 Very High Very High Very High
Disease 100 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cystic fibrosis patients, this increase in MIF production associated with carrying the 6 and 7 repeat variants was associated with enhanced end-organ injury.
Positive_regulation (increase) of Gene_expression (production) of MIF associated with fibrosis, injury and cystic fibrosis
1) Confidence 0.58 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.26 Pain Relevance 0.30
For example, in a mouse model of intestinal cancer, MIF expression was found to be increased in tumour tissue relative to normal intestine.
Positive_regulation (increased) of Gene_expression (expression) of MIF in intestine associated with cancer and intestinal cancer
2) Confidence 0.58 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.51 Pain Relevance 0.10
Transformation induced by Ras was restored upon deletion of p53.25,26

MIF receptor signalling and tumour pathogenesis

Positive_regulation (upon) of Gene_expression (signalling) of MIF receptor associated with cancer
3) Confidence 0.48 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.44 Pain Relevance 0.12
Transformation induced by Ras was restored upon deletion of p53.25,26

MIF receptor signalling and tumour pathogenesis

Positive_regulation (by) of Gene_expression (signalling) of MIF receptor associated with cancer
4) Confidence 0.48 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.45 Pain Relevance 0.12
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Mif associated with chemokine
5) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.86 Pain Relevance 0.61
The data show increased MIF plasma levels in GBS patients as compared to healthy controls (p<0.0001) and a progressive increase of MIF circulating concentration with patient's disability (p<0.0001).
Positive_regulation (increased) of Gene_expression (levels) of MIF in plasma associated with syndrome
6) Confidence 0.44 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16171874 Disease Relevance 1.34 Pain Relevance 0.69
Individuals carrying five copies of the CATT repeat element were found to display lower MIF levels, with those possessing increasing numbers of repeats (6, 7 or 8) having a corresponding increase in expression.
Positive_regulation (increase) of Gene_expression (levels) of MIF
7) Confidence 0.42 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.17 Pain Relevance 0.28
stabilization induced by hypoxia.42 MIF expression has been found to be up-regulated during hypoxia, with a HRE found in the 5?
Positive_regulation (hypoxia.42) of Gene_expression (expression) of MIF associated with hypoxia
8) Confidence 0.42 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.28 Pain Relevance 0.03
stabilization induced by hypoxia.42 MIF expression has been found to be up-regulated during hypoxia, with a HRE found in the 5?
Positive_regulation (induced) of Gene_expression (expression) of MIF associated with hypoxia
9) Confidence 0.42 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.29 Pain Relevance 0.03
Though over-expressed in the microarray, only a marginal increase in expression of Mif was observed at 96 hr post infection by PCR, where increases in inflammation and neutrophil migration were also observed.
Positive_regulation (increase) of Gene_expression (expression) of Mif in neutrophil associated with inflammation and infection
10) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.70 Pain Relevance 0.44
Rheumatoid arthritis patients carrying the 6 and 7 repeat variants had both higher basal levels of MIF and higher levels following stimulation with forskolin or serum.
Positive_regulation (following) of Gene_expression (levels) of MIF associated with rheumatoid arthritis
11) Confidence 0.39 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.42 Pain Relevance 0.31

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