INT130239

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.83
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 3
DRG 3
neurons 1
gastric fundus 1
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 11 99.96 Very High Very High Very High
Pain 43 99.92 Very High Very High Very High
trigeminal ganglion 6 99.08 Very High Very High Very High
Hippocampus 6 97.92 Very High Very High Very High
qutenza 34 97.76 Very High Very High Very High
Kinase C inhibitor 1 95.64 Very High Very High Very High
c fibre 19 94.32 High High
unmyelinated 1 94.00 High High
allodynia 12 90.88 High High
nMDA receptor 1 86.00 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 30 99.96 Very High Very High Very High
Pain 33 99.92 Very High Very High Very High
Neuropathic Pain 13 90.88 High High
Increased Venous Pressure Under Development 3 90.12 High High
Disease 3 83.00 Quite High
Fever 1 82.32 Quite High
Nociception 20 72.96 Quite High
Attention Deficit Hyperactivity Disorder 7 72.92 Quite High
Convulsion 19 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM8 mRNA was faintly detected.
Transcription (detected) of TRPM8 mRNA
1) Confidence 0.66 Published 2006 Journal Chem. Senses Section Abstract Doc Link 16831854 Disease Relevance 0.74 Pain Relevance 0.37
TRPM8 mRNA has been identified in both small and medium diameter DRG neurons in vivo, which are presumed to correspond to the cell bodies of C- and A?
Transcription (identified) of TRPM8 in neurons
2) Confidence 0.66 Published 2006 Journal Mol Pain Section Body Doc Link PMC1764875 Disease Relevance 0.33 Pain Relevance 0.66
Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.
Transcription (levels) of TRPM8 in DRG associated with dorsal root ganglion and qutenza
3) Confidence 0.64 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.28 Pain Relevance 0.68
Using in situ hybridization histochemistry and immunohistochemistry, we characterized the precise distribution of TRPA1, TRPM8, and TRPV1 mRNAs in the rat dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons.
Transcription (distribution) of TRPM8 in DRG associated with ganglion cysts, dorsal root ganglion and trigeminal ganglion
4) Confidence 0.52 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.53 Pain Relevance 0.56
In the DRG, TRPM8 mRNA was not expressed in the TRPV1-expressing neuronal population, whereas TRPA1 mRNA was only seen in some neurons in this population.
Neg (not) Transcription (expressed) of TRPM8 in DRG associated with dorsal root ganglion
5) Confidence 0.52 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.62 Pain Relevance 0.63
Using reverse transcription-polymerase chain reaction techniques, it was observed that the mRNA for the TRPM8 receptor and Rho-kinase were expressed in the rat gastric fundus. 6.
Transcription (expressed) of TRPM8 receptor in gastric fundus
6) Confidence 0.50 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16173944 Disease Relevance 0 Pain Relevance 0.09
The purpose of this paper is to further uncover the antipyretic mechanisms of 1 by investigating its effects on the mRNA expression levels and functions of both TRPV1 and TRPM8.
Transcription (expression) of TRPM8
7) Confidence 0.50 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.26 Pain Relevance 0
TRPM8 transcripts are expressed in <15% of small diameter sensory neurons, consistent with the proportion of excitable cells shown to be cold and menthol-sensitive [14,28].
Transcription (expressed) of TRPM8 in sensory neurons
8) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.27
TRPM8 transcripts are expressed in <15% of small diameter sensory neurons, consistent with the proportion of excitable cells shown to be cold and menthol-sensitive [14,28].
Transcription (transcripts) of TRPM8 in sensory neurons
9) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.26
Although TRPM8 protein is present in sensory neurons [11], we detected no TRPM8 mRNA in either cultured hippocampal neurons or rat hippocampus tissue of rats (Fig.
Neg (no) Transcription (detected) of TRPM8 in sensory neurons associated with hippocampus
10) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2560999 Disease Relevance 0.07 Pain Relevance 0.23

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