INT130241

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.15
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
fundus 2
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 82 99.98 Very High Very High Very High
Kinase C 23 98.80 Very High Very High Very High
agonist 63 98.32 Very High Very High Very High
Neurotransmitter 3 93.08 High High
Kinase C inhibitor 1 89.36 High High
Potency 5 85.68 High High
antagonist 4 72.32 Quite High
Pain 5 70.96 Quite High
member 8 3 69.00 Quite High
TRP channel 33 52.56 Quite High
Disease Link Frequency Relevance Heat
Toxicity 19 76.64 Quite High
Pain 6 70.96 Quite High
Ganglion Cysts 53 50.00 Quite Low
Nociception 17 50.00 Quite Low
Stress 1 33.20 Quite Low
Depression 4 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 4 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pruritus 2 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of this phospholipid on TRPM8 and TRPV1 are also functionally opposite: PIP(2) is necessary for the activation of TRPM8 but it constitutively inhibits TRPV1.
Positive_regulation (necessary) of Positive_regulation (activation) of TRPM8
1) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17074062 Disease Relevance 0 Pain Relevance 0.09
These results would suggest that cooling-induced contraction of the rat fundus is mediated by activation of TRPM8 receptors via a mechanism involving activation of Rho-kinase.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPM8 in fundus
2) Confidence 0.49 Published 2005 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16173944 Disease Relevance 0 Pain Relevance 0.08
Acute activation of both TRPV1 and TRPM8 induced large currents in response to saturating agonist concentration.
Positive_regulation (induced) of Positive_regulation (activation) of TRPM8 associated with agonist
3) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.15 Pain Relevance 0.56
We asked whether PKC, CaMKII, and PKA may play a role in shaping TRPM8-meidated responses during prolonged TRPM8 activation in both MS/CI and MS/CS neurons.
Positive_regulation (responses) of Positive_regulation (activation) of TRPM8 in neurons associated with kinase c
4) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.10
This region contains residues essential for capsaicin activation of TRPV1 [31] and menthol activation of TRPM8 [33].
Positive_regulation (activation) of Positive_regulation (activation) of TRPM8 associated with qutenza
5) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.61

General Comments

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