INT130246

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 3.35
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
diaphragm 2
nerves 2
MCF-7 2
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 32 100.00 Very High Very High Very High
member 8 13 100.00 Very High Very High Very High
diabetic neuropathy 8 96.56 Very High Very High Very High
Spinal cord 11 91.76 High High
agonist 5 90.08 High High
addiction 5 88.60 High High
imagery 25 83.48 Quite High
qutenza 6 75.00 Quite High
Dorsal horn 1 65.68 Quite High
Nerve growth factor 6 34.32 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 33 100.00 Very High Very High Very High
Injury 20 100.00 Very High Very High Very High
Adhesions 1 97.20 Very High Very High Very High
Diabetic Neuropathy 8 96.56 Very High Very High Very High
Adenocarcinoma 45 88.64 High High
Neuropathic Pain 15 88.08 High High
Breast Cancer 125 87.60 High High
Diabetes Mellitus 25 87.60 High High
Reprotox - General 1 33 86.68 High High
Nervous System Injury 9 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was reduced by 44 ± 7.5% of the control (p < 0.01) and that TRPM8 mRNA expression decreased by 47 ± 5.5% of the control (p < 0.001) (Fig. 4).
Negative_regulation (decreased) of Gene_expression (expression) of TRPM8 mRNA
1) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.26 Pain Relevance 0.04
RT-PCR experiments revealed a decrease in TRPM8 mRNA expression following steroid deprivation for 48 and 72 hours.
Negative_regulation (decrease) of Gene_expression (expression) of TRPM8 mRNA
2) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2887400 Disease Relevance 0.41 Pain Relevance 0.15
mRNA expression with small interfering RNA reduced the expression of TRPM8.
Negative_regulation (reduced) of Gene_expression (expression) of TRPM8
3) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2887400 Disease Relevance 0.43 Pain Relevance 0.07
Yet, silencing of endogenous TRPM8 mRNA by either antisense or siRNA strategies suppresses both I(cold/menthol) and TRPM8 protein in LNCaP cells.
Negative_regulation (suppresses) of Gene_expression (silencing) of TRPM8
4) Confidence 0.43 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.16 Pain Relevance 0.15
Incubation of MCF-7 cells in DCCFCS induced a significant decrease in TRPM8 mRNA level by 76 ± 8.4% of the control for 48 h and 71.1 ± 6.8% of the control for 72 h (p < 0.01, Fig. 3A).
Negative_regulation (decrease) of Gene_expression (level) of TRPM8 mRNA in MCF-7
5) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.06 Pain Relevance 0
was reduced by 44 ± 7.5% of the control (p < 0.01) and that TRPM8 mRNA expression decreased by 47 ± 5.5% of the control (p < 0.001) (Fig. 4).
Negative_regulation (decreased) of Gene_expression (expression) of TRPM8 mRNA
6) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.26 Pain Relevance 0.04
TRPM8 was detected in a few medium diameter DRG neurons, and was unchanged in DRG after avulsion injury, but was reduced in axons and myelin in injured nerves.
Negative_regulation (reduced) of Gene_expression (detected) of TRPM8 in nerves associated with dorsal root ganglion and injury
7) Confidence 0.34 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 1.39 Pain Relevance 0.57
The expression level of the slit-diaphragm proteins nephrin and transient receptor potential cation channel 6 as well as the cytoskeletal adaptor protein Nck significantly decreased.
Negative_regulation (decreased) of Gene_expression (expression) of receptor potential in diaphragm associated with member 8
8) Confidence 0.03 Published 2009 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19019920 Disease Relevance 0.38 Pain Relevance 0.10

General Comments

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