INT130260

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.85
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb2) signal transduction (Nfkb2) nucleus (Nfkb2)
extracellular matrix organization (Nfkb2) DNA binding (Nfkb2) cytoplasm (Nfkb2)
Anatomy Link Frequency
bone marrow 1
Nfkb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 47 99.68 Very High Very High Very High
agonist 49 96.28 Very High Very High Very High
Inflammation 97 96.00 Very High Very High Very High
cytokine 44 94.60 High High
Inflammatory response 7 93.92 High High
rheumatoid arthritis 157 93.00 High High
Osteoarthritis 17 86.88 High High
metalloproteinase 19 79.08 Quite High
methotrexate 16 72.24 Quite High
Spinal cord 6 60.24 Quite High
Disease Link Frequency Relevance Heat
Disease 81 97.16 Very High Very High Very High
INFLAMMATION 111 96.00 Very High Very High Very High
Coronary Artery Disease 23 95.32 Very High Very High Very High
Rheumatoid Arthritis 158 93.00 High High
Sprains And Strains 33 88.32 High High
Osteoarthritis 17 86.88 High High
Necrosis 18 84.40 Quite High
Injury 24 82.88 Quite High
Colon Cancer 6 80.60 Quite High
Apoptosis 7 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-p52 expression in all three mouse lines, consistent with a previous study (Ramdhan et al. 2008) and with increased expression of the proinflammatory cytokine TNF?.
Gene_expression (expression) of p52 associated with cytokine
1) Confidence 0.60 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.40 Pain Relevance 0.09
VLCAD, MCAD, PH, PT, ACOX A, and ACOX B expression was slightly lower and p65 and p52 expression was slightly higher in unexposed Ppar?
Gene_expression (expression) of p52
2) Confidence 0.47 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.27 Pain Relevance 0
B2 (p52), and RelA (p65) in bone marrow CD34+ cells is shown as the ratio of the copy numbers to those of ?
Gene_expression (shown) of p52 in bone marrow
3) Confidence 0.25 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.52 Pain Relevance 0.43
The human Shc locus encodes three proteins (p46, p52 and p66) by using two alternative promoters that synthesize two mRNAs coding for p46/p52 and for p66 [8].
Gene_expression (synthesize) of p52
4) Confidence 0.17 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.96 Pain Relevance 0
A dose-dependent effect on tumor growth inhibition was associated with reduced expression of NF-kappaBp65 and COX-2.
Gene_expression (expression) of NF-kappaBp65
5) Confidence 0.15 Published 2006 Journal Prostate Section Body Doc Link 16175586 Disease Relevance 0.12 Pain Relevance 0
RelB, c-Rel, p50, p52) are widely expressed in the CNS [94] and activated in a
Gene_expression (expressed) of p52 associated with central nervous system
6) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.49 Pain Relevance 0.41
B: the classical pathway (comprising homodimers and heterodimers of RelA, c-Rel and p50), and the alternate pathway (comprising RelB and p52).
Gene_expression (comprising) of p52
7) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.92 Pain Relevance 0.50
The expression of the Notch1, Delta1, ICN, Hes1 and NF-kappaB2 proteins was measured by Western blot.
Gene_expression (expression) of NF-kappaB2
8) Confidence 0.07 Published 2008 Journal Dig. Dis. Sci. Section Body Doc Link 18320325 Disease Relevance 0.16 Pain Relevance 0

General Comments

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