INT130264

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.94
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
synapse 4
dendrites 2
horn 2
Car3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 94 100.00 Very High Very High Very High
Hippocampus 36 98.64 Very High Very High Very High
Spinal cord 5 97.04 Very High Very High Very High
Dorsal horn 1 96.68 Very High Very High Very High
medulla 2 96.40 Very High Very High Very High
cerebral cortex 1 95.44 Very High Very High Very High
Central nervous system 17 94.24 High High
gABA 18 90.68 High High
intrathecal 1 86.80 High High
Neuropathic pain 6 84.92 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 84.92 Quite High
Injury 6 83.88 Quite High
Infection 56 79.64 Quite High
Disease 2 75.00 Quite High
Nervous System Injury 1 74.24 Quite High
Rabies Virus Infection 12 50.00 Quite Low
Stress 52 40.88 Quite Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Pseudorabies 6 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is however unlikely, in view of the established time needed to cross a single synapse, that the observed labeling in CA3 after 6?
Negative_regulation (labeling) of Spec (observed) Gene_expression (observed) of CA3 in synapse
1) Confidence 0.32 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.08 Pain Relevance 0.13
It is however unlikely, in view of the established time needed to cross a single synapse, that the observed labeling in CA3 after 6?
Negative_regulation (unlikely) of Spec (observed) Gene_expression (observed) of CA3 in synapse
2) Confidence 0.32 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.08 Pain Relevance 0.13
In situ hybridization showed a high level of RSEP1 expression in the CA1, CA3 and dentate gyrus regions of the hippocampus and the small sensory neurons in the dorsal horn, as well as the large neurons in the ventral horn of the spinal cord.
Negative_regulation (level) of Gene_expression (expression) of CA3 in horn associated with dorsal horn, hippocampus and spinal cord
3) Confidence 0.24 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176350 Disease Relevance 0.78 Pain Relevance 1.14
Occasionally, CA3 ripples were seen concurrent with those occurring in CA1, but the CA3 ripples were of a lower frequency (80–140?
Negative_regulation (were) of Gene_expression (ripples) of CA3
4) Confidence 0.20 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.23
The present data further confirm this: the membrane glycoprotein is located in the mossy fibers that originate in the dentate gyrus granule neurons and synapse on dendrites of CA3 pyramidal neurons.
Negative_regulation (dendrites) of Gene_expression (pyramidal neurons) of CA3 in dendrites associated with pyramidal cell
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2629568 Disease Relevance 0 Pain Relevance 0.11

General Comments

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