INT130270

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2)
nucleus (Map2k2)
Anatomy Link Frequency
L929 1
neurons 1
Map2k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 99.00 Very High Very High Very High
central sensitization 1 97.52 Very High Very High Very High
Dorsal horn 1 85.64 High High
Dorsal horn neuron 2 79.96 Quite High
Pain 4 79.84 Quite High
Kinase C 6 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 1 95.72 Very High Very High Very High
Pain 3 75.84 Quite High
Cancer 12 50.00 Quite Low
Glioma 6 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 1 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kv 4.3(+) neurons also expressed ERK 2 and mGluR 5, which are molecules related to the induction of central sensitization, a mechanism mediating nociceptive plasticity.
Gene_expression (expressed) of ERK 2 in neurons associated with nociception and central sensitization
1) Confidence 0.24 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176357 Disease Relevance 0.25 Pain Relevance 0.45
Figure 5d shows the effects of VPA exposure on the speed of L929 cells expressing constitutively active MEK2 (caMEK2).
Gene_expression (expressing) of MEK2 in L929
2) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0

General Comments

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