INT130272

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 9.25
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcna4)
Anatomy Link Frequency
TMJ 3
neurons 2
SH-SY5Y 1
coronary artery 1
dorsal root ganglion 1
Kcna4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 41 99.84 Very High Very High Very High
Dorsal horn neuron 2 99.84 Very High Very High Very High
trigeminal ganglion 56 99.80 Very High Very High Very High
Snapping jaw 46 99.56 Very High Very High Very High
dorsal root ganglion 23 99.56 Very High Very High Very High
addiction 3 99.36 Very High Very High Very High
Nav1.7 3 99.08 Very High Very High Very High
Adelta 3 98.48 Very High Very High Very High
intrathecal 2 98.36 Very High Very High Very High
Pain 35 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 99.84 Very High Very High Very High
Ganglion Cysts 85 99.56 Very High Very High Very High
Temporomandibular Joint Syndrome 46 99.56 Very High Very High Very High
Pain 31 97.88 Very High Very High Very High
Neuropathic Pain 63 97.44 Very High Very High Very High
Hypersensitivity 7 94.92 High High
Nociception 10 93.52 High High
Immunization 2 91.12 High High
Nervous System Injury 30 88.80 High High
Neuroblastoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, whether Kv 4 subunits are expressed in dorsal horn neurons remains unknown.
Gene_expression (expressed) of Kv 4 in neurons associated with dorsal horn neuron
1) Confidence 0.75 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176357 Disease Relevance 0.17 Pain Relevance 0.37
The aim of the present study was to investigate whether temporomandibular joint (TMJ) inflammation alters expression of Kv channel subtype 1.4 (Kv1.4) of trigeminal ganglion (TRG) neurons innervating TMJ relating allodynia (pain caused by normally innoxious stimulation), by using both behavioral and immunohistochemical techniques.
Gene_expression (expression) of Kv1.4 in TMJ associated with ganglion cysts, pain, snapping jaw, allodynia, inflammation and trigeminal ganglion
2) Confidence 0.75 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17584507 Disease Relevance 1.49 Pain Relevance 1.13
The m/rHK-1 was found to be mainly expressed in central immune organs like bone marrow, and was proven to have lymphopoietic roles in B and T lymphocyte development. m/rHK-1was also reported to have analgesic roles in rat spinal cord, in addition to other functions such as relaxing activity on coronary artery.
Gene_expression (expressed) of rHK-1 in coronary artery associated with analgesic and spinal cord
3) Confidence 0.75 Published 2009 Journal Hybridoma (Larchmt) Section Abstract Doc Link 19663698 Disease Relevance 0.06 Pain Relevance 0.14
Unlike its analogues SP, NKA, and NKB, m/rHK-1 does not express in the nervous system.
Neg (not) Gene_expression (express) of rHK-1 in nervous system
4) Confidence 0.75 Published 2009 Journal Hybridoma (Larchmt) Section Abstract Doc Link 19663698 Disease Relevance 0.09 Pain Relevance 0.14
The aim of the present study was to investigate whether temporomandibular joint (TMJ) inflammation alters expression of Kv channel subtype 1.4 (Kv1.4) of trigeminal ganglion (TRG) neurons innervating TMJ relating allodynia (pain caused by normally innoxious stimulation), by using both behavioral and immunohistochemical techniques.
Gene_expression (expression) of Kv channel subtype 1.4 in TMJ associated with ganglion cysts, pain, snapping jaw, allodynia, inflammation and trigeminal ganglion
5) Confidence 0.74 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17584507 Disease Relevance 1.49 Pain Relevance 1.13
To test this hypothesis, we first characterized the expression of two A-channels, Kv3.4 and Kv4.3, in rat dorsal root ganglion (DRG) neurons.
Gene_expression (expression) of Kv4 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
6) Confidence 0.73 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.07 Pain Relevance 0.81
After Kv3.4 or Kv4.3 expression in lumbar DRG neurons was suppressed by intrathecal injections of antisense oligodeoxynucleotides, mechanical but not thermal hypersensitivity developed.
Gene_expression (expression) of Kv4 in neurons associated with dorsal root ganglion, hypersensitivity and intrathecal
7) Confidence 0.73 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17855600 Disease Relevance 1.21 Pain Relevance 1.02
These findings suggest that TMJ inflammation reduces the expression of Kv1.4 subunits in the small-/medium sized (Adelta-/C-) TRG neurons and this may contribute to trigeminal inflammatory allodynia in TMJ disorder.
Gene_expression (expression) of Kv1.4 in TMJ associated with snapping jaw, allodynia, inflammation, trigeminal ganglion and adelta
8) Confidence 0.65 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17584507 Disease Relevance 1.91 Pain Relevance 1.57
Greater insights into molecular mechanism between KChIPs and Kv4 interaction may provide therapeutic potentials of designing compounds aimed at disrupting the protein-protein interaction for treatment of membrane excitability-related disorders.
Gene_expression (interaction) of Kv4
9) Confidence 0.52 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18415675 Disease Relevance 0.07 Pain Relevance 0.10
Since the pharmacology and gating properties of DRG A-type Kv channels are similar to those of heterogeneously expressed Kv4 channels [66,67], we could not completely rule out a potential role for Kv4.1, 4.2, and 4.3 in neuropathic pain.
Gene_expression (expressed) of Kv4 associated with dorsal root ganglion and neuropathic pain
10) Confidence 0.41 Published 2011 Journal Mol Pain Section Body Doc Link PMC3024960 Disease Relevance 1.41 Pain Relevance 0.89
Kv4.3 electrophysiological properties are modulated by K-channel interacting proteins (KChiPs) [40] and by co-expression with other K-channel subtypes, such as Kv 4.2 [42].
Gene_expression (expression) of Kv4
11) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0.05
Furthermore, RT-PCR analysis of 22 transcripts of voltage-gated ion channels in SH-SY5Y cells showed the expressions of Cav1.3, Kir2.1, Kv1.4, Kv2.1, Kv4.2, Kv7.1, BK(Ca), and Nav1.7, and those of BK(Ca) and Nav1.7 were higher in CD133(+) than in CD133(-) cells.
Gene_expression (expressions) of Kv4 in SH-SY5Y associated with nav1.7
12) Confidence 0.10 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20438714 Disease Relevance 0.28 Pain Relevance 0.26

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