INT130280

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 13
Disease Relevance 8.13
Pain Relevance 9.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
trigeminal ganglion 8
arcuate nucleus 4
satellite glial cells 4
sensory neurons 2
dorsal root ganglion 2
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 281 100.00 Very High Very High Very High
trigeminal ganglion 238 100.00 Very High Very High Very High
Antinociceptive 63 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
dorsal root ganglion 2 99.98 Very High Very High Very High
GABA receptor 56 99.84 Very High Very High Very High
Intracerebroventricular 2 99.56 Very High Very High Very High
spinal dorsal horn 45 99.36 Very High Very High Very High
antagonist 88 98.84 Very High Very High Very High
Inflammation 35 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 324 100.00 Very High Very High Very High
Targeted Disruption 4 100.00 Very High Very High Very High
Hyperinsulinism 2 100.00 Very High Very High Very High
Generalized Anxiety Disorder 107 99.32 Very High Very High Very High
INFLAMMATION 35 98.84 Very High Very High Very High
Nociception 69 98.68 Very High Very High Very High
Neuropathic Pain 68 96.96 Very High Very High Very High
Pain 194 96.36 Very High Very High Very High
Inflammatory Pain 21 90.28 High High
Peripheral Arterial Disease 21 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The direct administration of rAAV-GAD65 to dorsal root ganglion induced constitutive GAD65 expression, which was readily detected by immunohistochemistry.
Positive_regulation (induced) of Gene_expression (expression) of GAD65 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.69 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.78 Pain Relevance 0.82
The finding that adenovirus-mediated expression of GAD65 occurred principally in SGCs together with the presence of GABA receptor in the cell bodies of sensory neurons suggested that GABA might produce its antinociceptive effect inside the trigeminal ganglion in a paracrine manner.
Positive_regulation (mediated) of Gene_expression (expression) of GAD65 in sensory neurons associated with ganglion cysts, gaba, trigeminal ganglion, gaba receptor and antinociceptive
2) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.50 Pain Relevance 0.77
Concomitantly, the significant enhancement in GABA release following transgenic GAD65 expression was identified in vivo.
Positive_regulation (enhancement) of Gene_expression (expression) of GAD65 associated with targeted disruption and gaba
3) Confidence 0.47 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17466264 Disease Relevance 0.78 Pain Relevance 0.83
Immunohistochemical analysis showed that adenovirus-mediated GAD65 expression and GABA synthesis were mainly in SGCs.
Positive_regulation (mediated) of Gene_expression (expression) of GAD65 in SGCs associated with gaba
4) Confidence 0.44 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734545 Disease Relevance 1.04 Pain Relevance 0.95
Adenovirus-mediated expression of GAD65 occurs mainly in satellite glial cells (SGCs) in the trigeminal ganglion
Positive_regulation (mediated) of Gene_expression (expression) of GAD65 in satellite glial cells associated with ganglion cysts and trigeminal ganglion
5) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.91 Pain Relevance 0.59
The present study shows that adenoviral transfer of the GAD65 gene into satellite glial cells (SGCs) of the trigeminal ganglion is sufficient to reduce acute pain behavior resulting from the orofacial formalin test.
Positive_regulation (transfer) of Gene_expression (transfer) of GAD65 in trigeminal ganglion associated with ganglion cysts, acute pain and trigeminal ganglion
6) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.79 Pain Relevance 0.91
We found an adenovector that preferentially infected SGCs and used this virus to transfer GAD65, one of the two GAD isoforms, into SGCs in order to produce GABA within the trigeminal ganglion.
Positive_regulation (transfer) of Gene_expression (transfer) of GAD65 in trigeminal ganglion associated with ganglion cysts, gaba, generalized anxiety disorder and trigeminal ganglion
7) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.76 Pain Relevance 0.75
Injection of adenoviral vectors (AdGAD65) directly into the trigeminal ganglion leads to sustained expression of the GAD65 isoform over the 4 weeks observation period.
Positive_regulation (leads) of Gene_expression (expression) of GAD65 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
8) Confidence 0.44 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734545 Disease Relevance 1.04 Pain Relevance 0.90
In view of the previous results, we sought to determine if AdGAD65 produced its antinociceptive effect locally in the trigeminal ganglion through the activation of GABA receptors.
Positive_regulation (activation) of Spec (determine) Gene_expression (produced) of AdGAD65 in trigeminal ganglion associated with ganglion cysts, gaba receptor, trigeminal ganglion and antinociceptive
9) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.63 Pain Relevance 0.72
In situ hybridization was performed measuring the expression of striatal preproenkephalin, preprodynorphin and dopamine D-3 receptor mRNAs, subthalamic cytochrome oxidase mRNA and nigral glutamic acid decarboxylase mRNA.
Positive_regulation (measuring) of Gene_expression (expression) of glutamic acid decarboxylase mRNA associated with dopamine
10) Confidence 0.41 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18722529 Disease Relevance 0.08 Pain Relevance 0.05
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Positive_regulation (genes) of Gene_expression (encoding) of GAD65 associated with adenocard, gaba, inflammation and cytokine
11) Confidence 0.34 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.63 Pain Relevance 0.70
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Positive_regulation (increased) of Gene_expression (expression) of GAD65 mRNA in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
12) Confidence 0.28 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.10 Pain Relevance 0.72
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Positive_regulation (increases) of Gene_expression (expression) of GAD65 mRNA in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
13) Confidence 0.19 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.09 Pain Relevance 0.84

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