INT130284

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.10
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1, Npy) extracellular region (Ins1, Npy) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
arcuate nucleus 4
Ins1 (Rattus norvegicus)
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Action potential 3 99.44 Very High Very High Very High
dexamethasone 15 99.40 Very High Very High Very High
GABAergic 9 98.72 Very High Very High Very High
tetrodotoxin 9 96.56 Very High Very High Very High
sodium channel 3 95.52 Very High Very High Very High
Intracerebroventricular 3 95.32 Very High Very High Very High
gABA 6 91.76 High High
agonist 3 79.44 Quite High
antagonist 6 76.72 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems.
Insulin Negative_regulation (inhibits) of Gene_expression (expression) of neuropeptide Y in arcuate nucleus associated with gabaergic and neuropeptide
1) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Title Doc Link 16177033 Disease Relevance 0 Pain Relevance 0.83
These data suggest that insulin inhibits NPY gene expression in the arcuate nucleus through GABAergic systems.
insulin Negative_regulation (inhibits) of Gene_expression (expression) of NPY gene in arcuate nucleus associated with gabaergic
2) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.10 Pain Relevance 0.69
Conversely, insulin (10(-11) to 10(-9) M) significantly inhibited NPY expression stimulated by DEX, and the inhibitory action of insulin was abolished in the presence of TTX.
insulin Negative_regulation (inhibited) of Gene_expression (expression) of NPY associated with tetrodotoxin and dexamethasone
3) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0 Pain Relevance 0.95

General Comments

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