INT130290

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.38
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
T cell 4
plasma 2
blood 2
monocytes 2
Th2 cells 2
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 225 100.00 Very High Very High Very High
antidepressant 3 99.98 Very High Very High Very High
melanocortin 1 receptor 12 97.88 Very High Very High Very High
Inflammation 179 97.12 Very High Very High Very High
Chronic pancreatitis 12 96.80 Very High Very High Very High
depression 13 94.36 High High
fibrosis 7 93.20 High High
Inflammatory response 33 90.88 High High
Inflammatory mediators 23 86.76 High High
chemokine 33 84.76 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 59 99.78 Very High Very High Very High
Pressure And Volume Under Development 100 97.96 Very High Very High Very High
INFLAMMATION 242 97.12 Very High Very High Very High
Hemorrhage 2 97.00 Very High Very High Very High
Pancreatitis 13 96.80 Very High Very High Very High
Injury 9 96.68 Very High Very High Very High
Parasitic Infection 2 96.60 Very High Very High Very High
Apoptosis 36 95.84 Very High Very High Very High
Syndrome 10 95.36 Very High Very High Very High
Depression 13 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several reports describe associations between genetic variants in the IL-10 gene and increased secretion of IL-10 mRNA and protein.17–20 Of those, most studies have been restricted to the single nucleotide polymorphisms (SNP) at positions-1082 A>G, -819 C>T and -592 G>A in the IL-10 gene.
Positive_regulation (increased) of Localization (secretion) of IL-10
1) Confidence 0.47 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.80 Pain Relevance 0.16
Moreover, antidepressants increase secretion of IL-10 [67].
Positive_regulation (increase) of Localization (secretion) of IL-10 associated with antidepressant
2) Confidence 0.44 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.06 Pain Relevance 0.80
Although donor and CP PBMC responded equally to LPS, PACAP-mediated counteraction of LPS-induced cytokine response was switched from inhibiting TNF-alpha to decreasing IL-1beta and increasing IL-10 secretion.
Positive_regulation (increasing) of Localization (secretion) of IL-10 in PBMC associated with chronic pancreatitis and cytokine
3) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.11 Pain Relevance 0.98
Increased IL-10 release as an indicator of MOD or effusions is also supported by the finding that perioperative methyl-prednisolone administration, that enhances IL-10 release during CPB surgery in adults [33], aggravates postoperative effusions and bleeding in children with postcardiotomy syndrome [34].
Positive_regulation (Increased) of Localization (release) of IL-10 associated with syndrome and hemorrhage
4) Confidence 0.31 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.88 Pain Relevance 0.18
Increased IL-10 release as an indicator of MOD or effusions is also supported by the finding that perioperative methyl-prednisolone administration, that enhances IL-10 release during CPB surgery in adults [33], aggravates postoperative effusions and bleeding in children with postcardiotomy syndrome [34].
Positive_regulation (enhances) of Localization (release) of IL-10 associated with syndrome and hemorrhage
5) Confidence 0.31 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.85 Pain Relevance 0.14
Insignificant decrease of plasma IL-12 and IL-10, negligible increase of Th1-cytokines, and persistence of IL-10, despite decrease in TGF-?
Positive_regulation (increase) of Localization (decrease) of IL-10 in plasma associated with cytokine
6) Confidence 0.27 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.61 Pain Relevance 0.16
Side-specific LPS-stimulated IL-10 release
Positive_regulation (stimulated) of Localization (release) of IL-10
7) Confidence 0.21 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0
Human PBMCs, including monocytes, express the melanocortin 1 receptor (MC1R), and it is thought that the ability of alphaMSH to alter monocyte-costimulatory molecule expression and IL-10 release is mediated by this receptor.
Positive_regulation (mediated) of Localization (release) of IL-10 in monocytes associated with melanocortin 1 receptor
8) Confidence 0.20 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16177130 Disease Relevance 0.09 Pain Relevance 0.59
Our data further demonstrated that exposure of cells to ultrafine particles resulted in diminished IL-10 and VEGF release.
Positive_regulation (resulted) of Localization (release) of IL-10
9) Confidence 0.11 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.57 Pain Relevance 0.29
The mechanisms underlying Necator-induced T cell hyporesponsiveness have yet to be fully elucidated; however, diverse factors such as regulatory cytokines (e.g., IL-10) [12], secretion of IFN-?
Positive_regulation (induced) of Localization (secretion) of IL-10 in T cell associated with cytokine
10) Confidence 0.11 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.30 Pain Relevance 0.29
whereas they enhanced the release of IL-10.
Positive_regulation (enhanced) of Localization (release) of IL-10
11) Confidence 0.10 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892053 Disease Relevance 0.43 Pain Relevance 0.23
No significant variations in the secretion of IL-2 or IL-10 were observed (data not shown).
Neg (No) Positive_regulation (variations) of Localization (secretion) of IL-10
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.28 Pain Relevance 0
Our findings of a small number of CCR3+ cells infiltrating the skin at 48 hours could be due to the present of T cells releasing high levels of IL-10, low IFN-?
Positive_regulation (due) of Localization (present) of IL-10 in T cells
13) Confidence 0.08 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.46 Pain Relevance 0.23
The latter involves increased release of IL-10 and decreased release of TNF-?
Positive_regulation (increased) of Localization (release) of IL-10
14) Confidence 0.08 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.77 Pain Relevance 0.03
A synthetic peptide vaccine containing the major T cell epitopes of Fel d1, the major allergen of cats, which reduces clinical responsiveness to cat allergen exposure in cat allergic subjects, induces IL-10-secreting specific T cells, and suppresses proliferation of allergen-specific Th2 cells (M Larche, Hamilton, Canada).
Positive_regulation (induces) of Localization (secreting) of IL-10 in Th2 cells associated with hypersensitivity
15) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.75 Pain Relevance 0.30
Experiments revealed that blood mononuclear cells and lymphocytes with CFTR dysfunction exhibited a reduced potential for secretion of the cytokines IL-10 and IFN gamma [115,116].
Positive_regulation (potential) of Localization (secretion) of cytokines IL-10 in blood associated with cytokine
16) Confidence 0.07 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.43 Pain Relevance 0.37

General Comments

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