INT130299

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc2) ATPase activity (Abcc2) transmembrane transport (Abcc2)
Anatomy Link Frequency
bile 2
Abcc2 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 40 100.00 Very High Very High Very High
Paracetamol 5 99.80 Very High Very High Very High
imagery 3 80.64 Quite High
Inflammation 17 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
antidepressant 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lipodystrophy 2 99.68 Very High Very High Very High
Injury 3 75.00 Quite High
Breast Cancer 9 69.36 Quite High
Targeted Disruption 18 69.00 Quite High
Hematological Disease 6 65.24 Quite High
Toxicity 4 57.40 Quite High
Hepatotoxicity 2 40.52 Quite Low
Disorder Of Lipid Metabolism 8 32.04 Quite Low
Liver Disease 2 28.84 Quite Low
Obesity 1 28.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of APAP enhanced expression of Mrp2 (1.6-fold), Mrp3 (3.5-fold), and Mrp4 (16-fold).
Gene_expression (expression) of Mrp2 associated with paracetamol
1) Confidence 0.58 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.21 Pain Relevance 0.46
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of Abcc2 in bile associated with bile and lipodystrophy
2) Confidence 0.22 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.16 Pain Relevance 0.05
Bile acid induced activation of SXR also upregulates the expression of genes involved in bile acid metabolism and transport, such as MRP2, OATP2 and CYP3A [Frank et al., 2005; Guo et al., 2003; Kast et al., 2002; Kullak-Ublick, 2003].
Gene_expression (expression) of MRP2 in Bile associated with bile
3) Confidence 0.17 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.24 Pain Relevance 0.44

General Comments

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