INT1303

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Context Info
Confidence 0.55
First Reported 1976
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 278
Total Number 280
Disease Relevance 35.10
Pain Relevance 156.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
brain 16
endothelium 7
striatum 5
neurons 5
paw 5
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 362 100.00 Very High Very High Very High
Dopamine 246 100.00 Very High Very High Very High
opiate 201 100.00 Very High Very High Very High
Enkephalin 119 100.00 Very High Very High Very High
opioid receptor 115 100.00 Very High Very High Very High
Locus ceruleus 115 100.00 Very High Very High Very High
adenocard 108 100.00 Very High Very High Very High
dopamine receptor 77 100.00 Very High Very High Very High
IPN 57 100.00 Very High Very High Very High
Neurotransmitter 26 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 19 100.00 Very High Very High Very High
Neuropathic Pain 33 99.88 Very High Very High Very High
Hyperalgesia 129 99.72 Very High Very High Very High
Shock 7 99.64 Very High Very High Very High
Hypertrophy 22 99.50 Very High Very High Very High
Coronary Heart Disease 30 99.24 Very High Very High Very High
Neuroblastoma 11 99.24 Very High Very High Very High
Nociception 71 99.16 Very High Very High Very High
Bordatella Infection 40 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 14 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is substantiated by inhibition of adaptive relaxation by NG-monomethyl-L-arginine or N omega-nitro-L-arginine methyl ester, both inhibitors of NO synthesis, and by methylene blue, an inhibitor of soluble guanylate cyclase.
Negative_regulation (inhibitor) of guanylate cyclase
1) Confidence 0.55 Published 1991 Journal Nature Section Abstract Doc Link 1675430 Disease Relevance 0.16 Pain Relevance 0.18
Lithium ions (Li+) in vitro at 2-4 mM inhibited cyclase stimulated by isoproterenol and forskolin, but had no effect on the inhibition induced by met-enkephalin of the enzyme stimulated by forskolin, mediated by the inhibitory guanine nucleotide binding subunit (Ni).
Negative_regulation (inhibited) of cyclase associated with enkephalin
2) Confidence 0.52 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3035412 Disease Relevance 0 Pain Relevance 0.25
The analgesic effect of sodium nitroprusside and ACh was enhanced by intraplantar injection of an inhibitor of cyclic GMP phosphodiesterase (MY 5445) and was blocked by a guanylate cyclase inhibitor, methylene blue (MB).
Negative_regulation (inhibitor) of guanylate cyclase associated with analgesic
3) Confidence 0.52 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1981187 Disease Relevance 0.22 Pain Relevance 0.89
The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat.
Negative_regulation (inhibition) of cyclase associated with antinociceptive and morphine
4) Confidence 0.51 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9537812 Disease Relevance 0 Pain Relevance 0.56
Single s.c. injections of the 5-hydroxytryptamine (5-HT)1A receptor agonists buspirone at 4 mg/kg, 8-hydroxy-2-(di-n-propylamino)tetralin at 1 or 4 mg/kg or ipsapirone at 10 mg/kg did not affect 5-HT inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
Negative_regulation (inhibition) of cyclase associated with agonist
5) Confidence 0.51 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1530973 Disease Relevance 0 Pain Relevance 0.38
The negative chronotropy induced by propofol (IC50) stimulation was reduced to 40-50% by pretreatment with atropine, methoctramine, L-NMMA, or 1H[1,2,4]oxadiazolo[4,3-alpha]quanoxalin-1-one, a selective inhibitor of guanylyl cyclase.
Negative_regulation (inhibitor) of cyclase
6) Confidence 0.50 Published 1999 Journal Anesthesiology Section Body Doc Link 10598614 Disease Relevance 0 Pain Relevance 0
This paper reports an inhibitory effect of P. colorata flower alkaloids on [3H]naloxone binding in rat striata as well as a decrease in adenylate cyclase basal activity.
Negative_regulation (decrease) of cyclase associated with narcan
7) Confidence 0.50 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8833229 Disease Relevance 0.09 Pain Relevance 0.61
These results suggest that measurements of cyclic AMP released from brain slices do not accurately reflect effects on adenylate cyclase inhibition by opiates.
Negative_regulation (inhibition) of cyclase in brain associated with opiate
8) Confidence 0.50 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3022183 Disease Relevance 0 Pain Relevance 0.56
Nitric oxide (NO) inhibitors pyrogallol (a superoxide anion generator) and methylene blue (a guanylate cyclase inhibitor) completely blocked the effect of TNG in the presence of placenta.
Negative_regulation (inhibitor) of cyclase in placenta
9) Confidence 0.49 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9459239 Disease Relevance 0.28 Pain Relevance 0.16
Inhibition of guanylate cyclase with 10 microM of methylene blue could not reduce the effects of NO-donors.
Negative_regulation (Inhibition) of cyclase
10) Confidence 0.46 Published 1997 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9444520 Disease Relevance 0 Pain Relevance 1.05
In a preparation of membranes from the caudate nucleus, Li+ at 2-4 mM inhibited dopamine-stimulated adenylate cyclase, but this effect was not observed in the presence of additional sodium (Na+).
Negative_regulation (inhibited) of cyclase in caudate nucleus associated with dopamine
11) Confidence 0.45 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3035412 Disease Relevance 0 Pain Relevance 0.39
Removal of endothelium, inhibition of guanylate cyclase, inhibition of NO biosynthesis and inactivation of NO significantly reduced these relaxations.
Negative_regulation (inhibition) of guanylate cyclase in endothelium
12) Confidence 0.44 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7705433 Disease Relevance 0 Pain Relevance 0.23
The addition of either methylene blue or 6-anilino-5, 8-quinolinedione (LY 83583), two inhibitors of soluble guanylate cyclase, to splenocyte cultures dose-dependently antagonizes the suppressive effect of morphine on Con A-stimulated proliferation.
Negative_regulation (inhibitors) of cyclase associated with morphine
13) Confidence 0.44 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853159 Disease Relevance 0 Pain Relevance 0.64
Methylene blue (10 microM), an inhibitor of guanylate cyclase, produced a 3-fold increase in the basal release but had no significant effect on the hydroxylamine response.
Negative_regulation (inhibitor) of cyclase
14) Confidence 0.43 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 8100588 Disease Relevance 0 Pain Relevance 0.20
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Negative_regulation (inhibition) of cyclase in brain associated with neuroblastoma, glioma and clonidine
15) Confidence 0.43 Published 1981 Journal Eur. J. Biochem. Section Title Doc Link 6260485 Disease Relevance 0.37 Pain Relevance 0.82
Clonidine and several analogues of clonidine are shown to be useful probes for alpha 2-adrenergic receptors in a comparative study of ligand binding and inhibition of adenylate cyclase.
Negative_regulation (inhibition) of cyclase associated with clonidine
16) Confidence 0.43 Published 1981 Journal Eur. J. Biochem. Section Abstract Doc Link 6260485 Disease Relevance 0.32 Pain Relevance 0.56
The results are consistent with the concept that certain components required for the receptor-mediated inhibition of adenylate cyclase convert alpha 2-receptors from a high-affinity inactive state to a low-affinity active state.
Negative_regulation (inhibition) of cyclase
17) Confidence 0.43 Published 1981 Journal Eur. J. Biochem. Section Abstract Doc Link 6260485 Disease Relevance 0.25 Pain Relevance 0.68
Concentration-response relationships to an opener of adenosine triphosphate-dependent potassium channels, levcromakalim, or to an opener of calcium-dependent potassium channels, NS 1619, were studied in the absence and presence of inhibitors of adenylate cyclase (MDL 12330 A, 2 x 10(-5) mol/L; SQ 22536, 10(-4) mol/L) or guanylate cyclase (LY 83583,3 x 10(-6) mol/L).
Negative_regulation (inhibitors) of guanylate cyclase
18) Confidence 0.43 Published 2000 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 10764473 Disease Relevance 0.08 Pain Relevance 0
Pretreatment of animals with methylene blue (3.75 mg/kg i.p., an inhibitor of NO synthase and soluble guanylate cyclase - sGC) or (1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one) (ODQ, 2 mg/kg, i.p., a specific inhibitor of sGC) significantly caused a synergistic effect with a sub-effective dose of tramadol (5 mg/kg, p.o.) in the FST.
Negative_regulation (inhibitor) of guanylate cyclase associated with tramadol
19) Confidence 0.42 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18773934 Disease Relevance 0.05 Pain Relevance 1.06
Following chronic exposure of cultured cells to etorphine or U50488, the K agonists lost their ability to inhibit the cyclase.
Negative_regulation (inhibit) of cyclase associated with agonist and immobilon
20) Confidence 0.40 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2828959 Disease Relevance 0.10 Pain Relevance 0.82

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