INT130300
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Immunostaining of liver sections obtained 48 h after hepatotoxicant treatment confirmed expression patterns of a subset of transporters (Bcrp, Ntcp, Mrp3, and Mrp4). | |||||||||||||||
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Administration of APAP enhanced expression of Mrp2 (1.6-fold), Mrp3 (3.5-fold), and Mrp4 (16-fold). | |||||||||||||||
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With the exceptions of Oatp1a1, Ntcp, and Mrp1, these data mirror previous results suggesting that the solution used to dissolve APAP may alter the susceptibility of mice to hepatotoxicity, but only minimally change the regulation of transporter gene expression. | |||||||||||||||
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There was no difference in the mRNA and protein expression of efflux transporters between wild-type and Mrp3(-/-) mice. | |||||||||||||||
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Previous studies demonstrated differential expression of hepatobiliary transporter mRNA in mice treated with a toxic dose of APAP dissolved in 50% propylene glycol. | |||||||||||||||
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The purpose of this study was to determine whether using saline as a diluent for APAP alters regulation of transporter gene expression during hepatotoxicity. | |||||||||||||||
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Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity. | |||||||||||||||
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Alterations in transporter gene expression in this study were similar to those reported previously using propylene glycol as diluent. | |||||||||||||||
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As a control, the expression of Abcb11, an ABC transporter known to be responsible for the export of bile salts, was compared to that of Abcg5/sterolin-1 (Figure 6j,6k). | |||||||||||||||
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Previous studies on sitosterolemia have suggested a defect involving a putative sterol 'transporter' expressed in the intestinal brush border and/or the hepatic canalicular membrane [10,11]. | |||||||||||||||
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Also in the early effector cluster, retinol binding protein-1 (Rbp1), a Fabp/p2/Crbp/Crabp family retinol transporter is expressed in wound epidermal cells approximately 15 cell diameters back from the wound site (Figure 4k and 4l). | |||||||||||||||
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In vivo administration of the antioxidant tempol (1 mmol/l in drinking water) for a period of 4-weeks to mice rendered insulin-resistant by deficiency of the insulin-sensitive GLUT4 transporter significantly and potently attenuated cardiac hypertrophy in concert with tempol up-regulated ventricular expression of thioredoxin-2 (confirming an antioxidant action) [101]. | |||||||||||||||
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IsdDEF is a membrane transporter composed of solute-binding proteins (IsdD and IsdE) and a permease (IsdF) whereas HtsABC is an ABC-type transporter made up of a solute-binding protein (HtsA) and a dual protein permease (HtsB and HtsC). | |||||||||||||||
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An example is an amino acid, glutamate transporter expressed in Xenopus oocytes, in which a Cl? | |||||||||||||||
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General Comments
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