INT130300

Context Info Confidence 0.70 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 14 Total Number 14 Disease Relevance 5.34 Pain Relevance 4.96

transport (Abcc3) ATPase activity (Abcc3) transmembrane transport (Abcc3)

Anatomy Link Frequency epidermal cells 1 liver 1 bile 1 oocytes 1 brush 1 Abcc3 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 2 99.98 Paracetamol 66 99.80 Bile 91 98.28 imagery 14 96.88 agonist 6 74.48 cytokine 2 67.52 ischemia 9 66.80 Arthritis 2 66.28 Inflammation 75 50.00 Angina 2 18.16

Disease Link Frequency Relevance Heat Coronary Heart Disease 4 100.00 Injury 169 99.84 Hepatotoxicity 20 99.68 Targeted Disruption 86 98.80 Breast Cancer 7 97.52 Diabetic Cardiomyopathies 14 91.00 Diabetes Mellitus 136 87.76 Vitelliform Macular Dystrophy 2 86.24 Insulin Resistance 4 85.40 Myocardial Infarction 45 75.28

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunostaining of liver sections obtained 48 h after hepatotoxicant treatment confirmed expression patterns of a subset of transporters (Bcrp, Ntcp, Mrp3, and Mrp4).

Gene_expression (expression) of Mrp3 in liver

1) Confidence 0.70 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.20 Pain Relevance 0.44

Administration of APAP enhanced expression of Mrp2 (1.6-fold), Mrp3 (3.5-fold), and Mrp4 (16-fold).

Gene_expression (expression) of Mrp3 associated with paracetamol

2) Confidence 0.70 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.21 Pain Relevance 0.46

With the exceptions of Oatp1a1, Ntcp, and Mrp1, these data mirror previous results suggesting that the solution used to dissolve APAP may alter the susceptibility of mice to hepatotoxicity, but only minimally change the regulation of transporter gene expression.

Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity

3) Confidence 0.70 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.31 Pain Relevance 0.53

There was no difference in the mRNA and protein expression of efflux transporters between wild-type and Mrp3(-/-) mice.

Gene_expression (expression) of Mrp3

4) Confidence 0.60 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19889793 Disease Relevance 0 Pain Relevance 0.09

Previous studies demonstrated differential expression of hepatobiliary transporter mRNA in mice treated with a toxic dose of APAP dissolved in 50% propylene glycol.

Gene_expression (expression) of transporter associated with paracetamol

5) Confidence 0.53 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.25 Pain Relevance 0.66

The purpose of this study was to determine whether using saline as a diluent for APAP alters regulation of transporter gene expression during hepatotoxicity.

Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity

6) Confidence 0.47 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.26 Pain Relevance 0.79

Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity.

Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity

7) Confidence 0.47 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Title Doc Link 17934960 Disease Relevance 0.28 Pain Relevance 0.84

Alterations in transporter gene expression in this study were similar to those reported previously using propylene glycol as diluent.

Gene_expression (expression) of transporter gene

8) Confidence 0.47 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.24 Pain Relevance 0.72

As a control, the expression of Abcb11, an ABC transporter known to be responsible for the export of bile salts, was compared to that of Abcg5/sterolin-1 (Figure 6j,6k).

Gene_expression (expression) of transporter in bile associated with bile

9) Confidence 0.09 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.35 Pain Relevance 0.05

Previous studies on sitosterolemia have suggested a defect involving a putative sterol 'transporter' expressed in the intestinal brush border and/or the hepatic canalicular membrane [10,11].

Gene_expression (expressed) of transporter in brush

10) Confidence 0.09 Published 2004 Journal BMC Med Section Body Doc Link PMC394351 Disease Relevance 0.43 Pain Relevance 0.16

Also in the early effector cluster, retinol binding protein-1 (Rbp1), a Fabp/p2/Crbp/Crabp family retinol transporter is expressed in wound epidermal cells approximately 15 cell diameters back from the wound site (Figure 4k and 4l).

Gene_expression (expressed) of transporter in epidermal cells associated with injury

11) Confidence 0.05 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.66 Pain Relevance 0.03

In vivo administration of the antioxidant tempol (1 mmol/l in drinking water) for a period of 4-weeks to mice rendered insulin-resistant by deficiency of the insulin-sensitive GLUT4 transporter significantly and potently attenuated cardiac hypertrophy in concert with tempol up-regulated ventricular expression of thioredoxin-2 (confirming an antioxidant action) [101].

Gene_expression (expression) of transporter associated with coronary heart disease

12) Confidence 0.03 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801857 Disease Relevance 1.83 Pain Relevance 0.09

IsdDEF is a membrane transporter composed of solute-binding proteins (IsdD and IsdE) and a permease (IsdF) whereas HtsABC is an ABC-type transporter made up of a solute-binding protein (HtsA) and a dual protein permease (HtsB and HtsC).

Gene_expression (made) of transporter

13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2723934 Disease Relevance 0.24 Pain Relevance 0

An example is an amino acid, glutamate transporter expressed in Xenopus oocytes, in which a Cl?

Gene_expression (expressed) of transporter in oocytes associated with glutamate

14) Confidence 0.01 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.09 Pain Relevance 0.10

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