INT130301

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc3) ATPase activity (Abcc3) transmembrane transport (Abcc3)
Abcc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.98 Very High Very High Very High
imagery 1 82.00 Quite High
Bile 1 72.88 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 99.58 Very High Very High Very High
Breast Cancer 2 84.40 Quite High
Injury 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of APAP enhanced expression of Mrp2 (1.6-fold), Mrp3 (3.5-fold), and Mrp4 (16-fold).
Positive_regulation (enhanced) of Gene_expression (expression) of Mrp3 associated with paracetamol
1) Confidence 0.63 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.21 Pain Relevance 0.46
With the exceptions of Oatp1a1, Ntcp, and Mrp1, these data mirror previous results suggesting that the solution used to dissolve APAP may alter the susceptibility of mice to hepatotoxicity, but only minimally change the regulation of transporter gene expression.
Positive_regulation (change) of Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity
2) Confidence 0.42 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.31 Pain Relevance 0.54

General Comments

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