INT130323

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm7) Golgi apparatus (Grm7) plasma membrane (Grm7)
neurological system process (Grm7) protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
central nervous system 1
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 17 100.00 Very High Very High Very High
Glutamate receptor 17 100.00 Very High Very High Very High
nMDA receptor 19 99.52 Very High Very High Very High
Central nervous system 3 98.44 Very High Very High Very High
agonist 49 95.60 Very High Very High Very High
Neuronal excitability 1 93.84 High High
antagonist 74 90.32 High High
Eae 16 86.00 High High
nMDA receptor antagonist 7 80.28 Quite High
Glutamate 36 77.76 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 33 99.12 Very High Very High Very High
Cognitive Disorder 21 87.56 High High
Sprains And Strains 71 85.28 High High
Congenital Anomalies 6 84.80 Quite High
Targeted Disruption 8 80.88 Quite High
Disease 2 79.68 Quite High
Psychosis 1 69.32 Quite High
Attention Deficit Hyperactivity Disorder 12 66.40 Quite High
Pain 1 62.88 Quite High
Neurological Disease 2 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in the signal of four genes (Atp1a2, Kcnj9, Grm7, Comt) selected for further investigation were found to be regulated by strong cis-acting elements.
Regulation (regulated) of Grm7 associated with catechol-o-methyltransferase and glutamate receptor
1) Confidence 0.26 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.27 Pain Relevance 0.16
Therefore, the mGlu5 receptor may be an important therapeutic target for the treatment of disorders of the central nervous system.
Regulation (target) of mGlu5 receptor in central nervous system associated with central nervous system
2) Confidence 0.01 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 16178734 Disease Relevance 0.49 Pain Relevance 0.48
Because mGlu receptors have modulatory roles on NMDA receptor-mediated transmission, mGlu receptor ligands may be attractive therapeutic targets for the treatment of schizophrenia.


Spec (may) Regulation (targets) of mGlu receptor associated with nmda receptor and schizophrenia
3) Confidence 0.00 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3002053 Disease Relevance 1.14 Pain Relevance 0.56

General Comments

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