INT130332

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.84
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam17) extracellular region (Adam17) cell motility (Adam17)
cell adhesion (Adam17) plasma membrane (Adam17) cytoplasm (Adam17)
Anatomy Link Frequency
cleavage 2
ACN 1
platelets 1
Adam17 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 223 99.74 Very High Very High Very High
aspirin 9 94.48 High High
Central nervous system 14 90.76 High High
Inflammation 129 77.72 Quite High
fibrosis 28 77.16 Quite High
cytokine 80 73.20 Quite High
cINOD 6 60.68 Quite High
Inflammatory mediators 10 58.60 Quite High
cva 17 56.56 Quite High
rheumatoid arthritis 283 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hypertrophy 16 99.48 Very High Very High Very High
Targeted Disruption 112 97.52 Very High Very High Very High
Dilated Cardiomyopathy 6 95.20 Very High Very High Very High
Cv General 4 Under Development 384 92.56 High High
Pulmonary Disease 98 88.24 High High
Stress 4 87.20 High High
Infection 31 86.48 High High
Glioblastoma 4 85.60 High High
Adhesions 30 85.24 High High
Fibrosis 27 79.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although shedding occurred normally in COX-1-deficient murine platelets, shedding was completely blocked by a broad-range metalloproteinase inhibitor and, more importantly, in mouse platelets expressing an inactive form of ADAM17.
Gene_expression (expressing) of ADAM17 in platelets associated with metalloproteinase
1) Confidence 0.50 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16179345 Disease Relevance 0.19 Pain Relevance 0.43
During chimeric male spermatogenesis, Cre recombinase (Cre) driven by the murine angiotensin-converting enzyme promoter, tACE, confers loxP-mediated excision of the ACN cassette to yield a single remaining loxP site.
Gene_expression (excision) of tACE in ACN
2) Confidence 0.38 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0 Pain Relevance 0
Various other studies confirm that ADAM17 likely affects regulated, but not constitutive, ?
Neg (not) Gene_expression (affects) of ADAM17
3) Confidence 0.35 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.15 Pain Relevance 0.07
In light of the latter observation, it is perhaps of little surprise that it has more recently been shown that ADAM10 and not ADAM17 or 9 is the physiologically relevant basal ?
Gene_expression (relevant) of ADAM17
4) Confidence 0.29 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.43 Pain Relevance 0.09
In light of the latter observation, it is perhaps of little surprise that it has more recently been shown that ADAM10 and not ADAM17 or 9 is the physiologically relevant basal ?
Neg (not) Gene_expression (not) of ADAM17
5) Confidence 0.29 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.43 Pain Relevance 0.09
The balance between tmTNF and solTNF signaling is influenced by cell type, activation status of the cell, the stimulus eliciting TNF production, TACE activity, and expression of endogenous TACE inhibitors leading to divergent TNF-mediated effects on cellular viability [10,11].
Gene_expression (expression) of TACE
6) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.29 Pain Relevance 0.20
Similarly, Hiraoka et al. [74] demonstrated that overexpression of ADAM17 in COS7 cells lead to a significant increase in basal sAPP?
Gene_expression (overexpression) of ADAM17
7) Confidence 0.26 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.15 Pain Relevance 0
Only constitutive and not muscarine-regulated APP cleavage was enhanced in HEK cells transfected with ADAM17 [73].
Gene_expression (transfected) of ADAM17 in cleavage
8) Confidence 0.26 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.15 Pain Relevance 0.03
In humans, increased TACE expression parallels the increase in TNF-?
Gene_expression (expression) of TACE
9) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.87 Pain Relevance 0.09
that is resistant to cleavage by TACE, concentric hypertrophy without chamber dilatation was observed [151,152], whereas mice with overexpression of TNF-?
Gene_expression (resistant) of TACE in cleavage associated with hypertrophy
10) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.89 Pain Relevance 0.10
As both of these proteases are expressed by MKN7 cells we repeated co-culture experiments with and without knockdown of expression of either and both ADAM17 and MMP-14 using siRNA.
Gene_expression (expression) of ADAM17
11) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.37 Pain Relevance 0
Ultimately, the integral cell-surface metalloproteinases ADAM-10 and ADAM-17/TACE were found to underlie ?
Gene_expression (found) of ADAM-17 associated with metalloproteinase
12) Confidence 0.11 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.05
Ultimately, the integral cell-surface metalloproteinases ADAM-10 and ADAM-17/TACE were found to underlie ?
Gene_expression (/) of ADAM-17 associated with metalloproteinase
13) Confidence 0.11 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.05
The inhibitors of ADAMs have not been fully elucidated, but ADAM-17 is inhibited by TIMP-3 but not TIMP-1 or -2 (Amour et al 1998; Black 2004).


Neg (not) Gene_expression (is) of ADAM-17
14) Confidence 0.06 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.91 Pain Relevance 0.37

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