INT130341

Context Info Confidence 0.02 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.53

nucleus (TAL1) enzyme binding (TAL1) DNA binding (TAL1)

Anatomy Link Frequency striatum 2 TAL1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dopamine 11 99.28 Substantia nigra 1 84.88 substance P 1 80.32 Enkephalin 1 25.00

Disease Link Frequency Relevance Heat Apoptosis 1 94.00 Disease 5 82.12 Basal Ganglia Disease 1 60.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that activated caspase-3, its actin cleavage product fractin, and components of the apoptosome were increased significantly in DA-depleted striatum.

Positive_regulation (increased) of Positive_regulation (activated) of actin cleavage product in striatum associated with dopamine

1) Confidence 0.02 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16180225 Disease Relevance 0.49 Pain Relevance 0.53

General Comments

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