INT130343

Context Info Confidence 0.75 First Reported 2005 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 6.98 Pain Relevance 1.38

signal transduction (CTNND2) cell adhesion (CTNND2) nucleus (CTNND2) cytoplasm (CTNND2)

Anatomy Link Frequency chondrocyte 1 CSF 1 skin 1 CTNND2 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate receptor 2 99.52 Osteoarthritis 82 98.92 cINOD 37 97.92 Pain 7 88.52 Potency 4 88.20 Arthritis 2 86.44 anesthesia 1 82.08 Electroencephalography 1 77.44 COX-2 inhibitor 6 68.48 carbamazepine 1 66.64

Disease Link Frequency Relevance Heat Familial Adenomatous Polyposis 40 99.88 Desmoid Disease 74 99.84 Cancer 113 99.52 Osteoarthritis 82 98.92 Adhesions 2 98.80 Malignant Neoplastic Disease 9 98.72 Obesity 2 95.72 Aging 1 95.36 Apoptosis 1 94.32 Skin Cancer 47 92.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-catenin expression in desmoid tumours might determine the efficacy of NSAIDs, and contribute to tumour-growth inhibition and survival in desmoid patients with ?

Gene_expression (expression) of catenin associated with cancer, desmoid disease and cinod

1) Confidence 0.75 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.56 Pain Relevance 0.49

-catenin signal and the related molecules may regulate the development of OA through an endochondral ossification process including chondrocyte mutation and apoptosis.2

Gene_expression (signal) of catenin in chondrocyte associated with apoptosis and osteoarthritis

2) Confidence 0.65 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824859 Disease Relevance 1.12 Pain Relevance 0.46

-catenin expression could not be undertaken because of an insufficient sample volume.

Gene_expression (expression) of catenin

3) Confidence 0.58 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.88 Pain Relevance 0.19

Loss of E-cadherin, beta-catenin and altered syndecan-1 expression suggest an impaired cellular adhesion, which may explain the peculiar histological appearance of these tumors and contribute to the observed aggressive clinical behavior in skin, penile and breast ASCC [6,10,12].

Gene_expression (expression) of catenin in skin associated with cancer, skin cancer and adhesions

4) Confidence 0.58 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 1.42 Pain Relevance 0

Autoantibodies against the glutamate receptor subunits epsilon-2 and delta-2 were detected in the serum and CSF.

Gene_expression (detected) of delta-2 in CSF associated with glutamate receptor

5) Confidence 0.12 Published 2005 Journal Rinsho Shinkeigaku Section Abstract Doc Link 16180713 Disease Relevance 1.00 Pain Relevance 0.24

General Comments

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