INT130343

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.98
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CTNND2) cell adhesion (CTNND2) nucleus (CTNND2)
cytoplasm (CTNND2)
Anatomy Link Frequency
chondrocyte 1
CSF 1
skin 1
CTNND2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.52 Very High Very High Very High
Osteoarthritis 82 98.92 Very High Very High Very High
cINOD 37 97.92 Very High Very High Very High
Pain 7 88.52 High High
Potency 4 88.20 High High
Arthritis 2 86.44 High High
anesthesia 1 82.08 Quite High
Electroencephalography 1 77.44 Quite High
COX-2 inhibitor 6 68.48 Quite High
carbamazepine 1 66.64 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 40 99.88 Very High Very High Very High
Desmoid Disease 74 99.84 Very High Very High Very High
Cancer 113 99.52 Very High Very High Very High
Osteoarthritis 82 98.92 Very High Very High Very High
Adhesions 2 98.80 Very High Very High Very High
Malignant Neoplastic Disease 9 98.72 Very High Very High Very High
Obesity 2 95.72 Very High Very High Very High
Aging 1 95.36 Very High Very High Very High
Apoptosis 1 94.32 High High
Skin Cancer 47 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin expression in desmoid tumours might determine the efficacy of NSAIDs, and contribute to tumour-growth inhibition and survival in desmoid patients with ?
Gene_expression (expression) of catenin associated with cancer, desmoid disease and cinod
1) Confidence 0.75 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.56 Pain Relevance 0.49
-catenin signal and the related molecules may regulate the development of OA through an endochondral ossification process including chondrocyte mutation and apoptosis.2
Gene_expression (signal) of catenin in chondrocyte associated with apoptosis and osteoarthritis
2) Confidence 0.65 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824859 Disease Relevance 1.12 Pain Relevance 0.46
-catenin expression could not be undertaken because of an insufficient sample volume.


Gene_expression (expression) of catenin
3) Confidence 0.58 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.88 Pain Relevance 0.19
Loss of E-cadherin, beta-catenin and altered syndecan-1 expression suggest an impaired cellular adhesion, which may explain the peculiar histological appearance of these tumors and contribute to the observed aggressive clinical behavior in skin, penile and breast ASCC [6,10,12].
Gene_expression (expression) of catenin in skin associated with cancer, skin cancer and adhesions
4) Confidence 0.58 Published 2011 Journal Diagn Pathol Section Body Doc Link PMC3024921 Disease Relevance 1.42 Pain Relevance 0
Autoantibodies against the glutamate receptor subunits epsilon-2 and delta-2 were detected in the serum and CSF.
Gene_expression (detected) of delta-2 in CSF associated with glutamate receptor
5) Confidence 0.12 Published 2005 Journal Rinsho Shinkeigaku Section Abstract Doc Link 16180713 Disease Relevance 1.00 Pain Relevance 0.24

General Comments

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