INT130351

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 5.99
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf)
Anatomy Link Frequency
Plasma 5
endothelial cells 2
vessels 2
HeLa 1
brain 1
Vwf (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 66 99.88 Very High Very High Very High
Paracetamol 24 99.84 Very High Very High Very High
cytokine 60 99.40 Very High Very High Very High
medulla 29 97.84 Very High Very High Very High
Spinal cord 17 97.28 Very High Very High Very High
Inflammation 229 96.04 Very High Very High Very High
anesthesia 13 90.68 High High
Restless leg syndrome 2 72.04 Quite High
Glutamate receptor 4 65.20 Quite High
withdrawal 1 61.36 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 67 99.88 Very High Very High Very High
Systemic Sclerosis 53 99.84 Very High Very High Very High
Diabetes Mellitus 11 99.58 Very High Very High Very High
Disease 82 99.44 Very High Very High Very High
Renal Disease 4 99.04 Very High Very High Very High
Targeted Disruption 127 96.20 Very High Very High Very High
INFLAMMATION 131 96.04 Very High Very High Very High
Adhesions 1 94.56 High High
Heart Rate Under Development 37 94.32 High High
Vasculitis 4 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Positive_regulation (elevation) of vWF in Plasma associated with paracetamol and cytokine
1) Confidence 0.59 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.22 Pain Relevance 0.70
Increased plasma concentrations of vWf in SSc have been described in several studies [1,25,26].
Positive_regulation (Increased) of vWf in plasma associated with systemic sclerosis
2) Confidence 0.49 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.67 Pain Relevance 0
Compared with the vehicle group, LPS showed a significant increase in the level of vWF (p < 0.05).
Positive_regulation (increase) of vWF
3) Confidence 0.47 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.15 Pain Relevance 0.09
Additionally, although statistical significance was not achieved, enhanced activity of vWF induced by LPS was further increased by its combination with 14-nm nanoparticles.
Positive_regulation (increased) of vWF
4) Confidence 0.47 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.31 Pain Relevance 0.08
Interestingly, exposure to nanoparticles alone did not induce significant fibrinogen production/release or activate vWF.
Positive_regulation (activate) of vWF
5) Confidence 0.47 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.38 Pain Relevance 0.11
In a study of patients with type 1 diabetes [11], we found both vWf and propeptide to be increased in patients with overt nephropathy and in patients with microalbuminuria, whereas only the propeptide was increased in normoalbuminuric patients.
Positive_regulation (increased) of vWf associated with diabetes mellitus and renal disease
6) Confidence 0.46 Published 2001 Journal Arthritis Res Section Body Doc Link PMC30710 Disease Relevance 0.75 Pain Relevance 0.11
In addition, abnormal accumulation of Glut1 and vWF in the vascular endothelial cell was observed at the brainstem and spinal cord of symptomatic A53T mice (Figs. 4G-J), indicating the dysfunction of vascular endothelial cells.
Positive_regulation (accumulation) of vWF in endothelial cells associated with targeted disruption, medulla and spinal cord
7) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.41 Pain Relevance 0.32
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Positive_regulation (increased) of von Willebrand factor in Plasma associated with paracetamol and cytokine
8) Confidence 0.43 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.24 Pain Relevance 0.70
Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).
Positive_regulation (increased) of vWF in Plasma associated with paracetamol and cytokine
9) Confidence 0.40 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.24 Pain Relevance 0.69
We measured prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, activated protein C (APC), and activity for von Willebrand factor (vWF) (n = 14–16 in each group) using a commercial kit (Diagnostica Stago, Roche, Tokyo, Japan) and an STA Compact analyzer (Diagnostica Stago, Roche) as previously described (Inoue et al. 2004).


Positive_regulation (activated) of vWF
10) Confidence 0.34 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570092 Disease Relevance 0.30 Pain Relevance 0.12
Since CD31 can be expressed on non-endothelial cells as well, we confirmed that LacZ+ nuclei were present in vessels in the border zone by using von Willebrand factor (vWF) (Supplementary Fig. 2a).
Positive_regulation (using) of von Willebrand factor in vessels
11) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.30 Pain Relevance 0
Since CD31 can be expressed on non-endothelial cells as well, we confirmed that LacZ+ nuclei were present in vessels in the border zone by using von Willebrand factor (vWF) (Supplementary Fig. 2a).
Positive_regulation (using) of vWF in vessels
12) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.30 Pain Relevance 0
The induction of vWF in brain after IR exposure has been reported [27].
Positive_regulation (induction) of vWF in brain
13) Confidence 0.23 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0.07
Quantitative analysis showed after endothelial induction, ICAM1, CD31, VCAM1, and vWF were significantly upregulated, while FGF1, Flt1, KDR and VEGFA were expressed in undifferentiated cells and upregulated with endothelial differentiation of hESCs (Figure 4B), which were also consistent with the microarray data.
Positive_regulation (upregulated) of vWF
14) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Patients with RA have increased serum levels of fibrinogen, von Willebrand factor and tissue plasminogen activator antigen compared with controls and these prothrombotic markers have been shown to predict cardiovascular events in patients with RA (McEntegart et al 2001; Sattar et al 2003).


Positive_regulation (increased) of von Willebrand factor associated with rheumatoid arthritis
15) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.61 Pain Relevance 0.36
The vWF is a protein produced by endothelial cells at the inner layer of the blood vessels and is accumulated in storage granules in the cytoplasm of these cells.
Positive_regulation (accumulated) of vWF in endothelial cells
16) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.05 Pain Relevance 0.03
cells, including elevated vWF secretion [26].
Positive_regulation (elevated) of vWF
17) Confidence 0.17 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0.07
Increased amounts of vWF in blood plasma are
Positive_regulation (Increased) of vWF in plasma
18) Confidence 0.16 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0.04
THBS1 was downregulated in irradiated TK6 and HFL1 cells. vWF was induced in radiation-exposed HeLa cells, but its expression was downregulated in Jurkat cells.
Positive_regulation (induced) of vWF in HeLa
19) Confidence 0.16 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0

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