INT130358

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.84
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PSC 1
pancreas 1
Tsp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 94.24 High High
fibrosis 2 90.08 High High
Chronic pancreatitis 6 87.84 High High
Inflammation 138 63.52 Quite High
tolerance 9 27.40 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 11 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 12 99.58 Very High Very High Very High
Burns 3 99.12 Very High Very High Very High
Injury 31 98.72 Very High Very High Very High
Apoptosis 60 98.22 Very High Very High Very High
Fibrosis 10 95.20 Very High Very High Very High
Cancer 101 90.36 High High
Corneal Neovascularization 37 88.40 High High
Sarcoma 14 86.24 High High
Metastasis 29 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSC were isolated by outgrowth from normal mouse pancreas and expression of TSP-1 and TSP-2 was evaluated after serum-activation.
Gene_expression (expression) of TSP-2 in PSC associated with primary sclerosing cholangitis
1) Confidence 0.65 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.39 Pain Relevance 0.23
In summary, PSC may be an important source of both TSP-1 and TSP-2 in the pancreas in response to injury.
Gene_expression (source) of TSP-2 in pancreas associated with injury and primary sclerosing cholangitis
2) Confidence 0.51 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.34 Pain Relevance 0.25
Yan et al. [71] conducted an in vivo study of VEGF and TSP2 expression after corneal alkali burn.
Gene_expression (expression) of TSP2 associated with burns
3) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.73 Pain Relevance 0
1); this site is not preserved in TSP2.
Neg (not) Gene_expression (preserved) of TSP2
4) Confidence 0.41 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.15 Pain Relevance 0.08
Numerous cell assays attribute functions to TSP1 in cell proliferation, apoptosis, angiogenesis inhibition, cell attachment and motility.(22) Most of these functions are shared with TSP2,(13–17) especially the inhibition of (EC) proliferation and angiogenesis.
Gene_expression (shared) of TSP2 associated with apoptosis
5) Confidence 0.41 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.10 Pain Relevance 0.04
Therefore TSP2 is unable to activate TGF?
Neg (unable) Gene_expression (unable) of TSP2
6) Confidence 0.41 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.15 Pain Relevance 0.08
mice can be rescued with addition of TSP-1 and TSP-2, both potent activators of TGF-?
Gene_expression (addition) of TSP-2
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.21 Pain Relevance 0
In agreement with this, preliminary findings indicate a progressive increase in the expression of pro-angiogenic factors (such as VEGF and FGF2) and a concomitant decrease of angiogenesis-inhibitory factors (particularly TSP-1 and TSP-2) during cen3tel malignant progression, pointing to angiogenesis as a candidate pro-metastatic feature acquired by late-phase metastatic cen3tel cells.
Gene_expression (progression) of TSP-2 associated with malignant neoplastic disease
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.77 Pain Relevance 0

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