INT13036

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2011
Negated 6
Speculated 10
Reported most in Abstract
Documents 105
Total Number 116
Disease Relevance 23.71
Pain Relevance 77.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 14
mossy fiber 12
synapses 12
hippocampus 8
neurons 7
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 4778 100.00 Very High Very High Very High
Anterior cingulate cortex 1455 100.00 Very High Very High Very High
nMDA receptor 1277 100.00 Very High Very High Very High
amygdala 792 100.00 Very High Very High Very High
Hippocampus 730 100.00 Very High Very High Very High
depression 704 100.00 Very High Very High Very High
Pyramidal cell 314 100.00 Very High Very High Very High
Glutamate 261 100.00 Very High Very High Very High
addiction 53 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 702 100.00 Very High Very High Very High
Targeted Disruption 526 100.00 Very High Very High Very High
Li-fraumeni Syndrome 149 100.00 Very High Very High Very High
Stress 142 99.98 Very High Very High Very High
Pain 685 99.84 Very High Very High Very High
Drug Dependence 19 99.52 Very High Very High Very High
Anaerobic Bacterial Infections 34 98.56 Very High Very High Very High
Nociception 192 96.40 Very High Very High Very High
INFLAMMATION 152 96.16 Very High Very High Very High
Anxiety Disorder 655 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among them, activation of AC1 and CaMKIV have been reported to be essential for the induction of LTP in the ACC [4,9].
Positive_regulation (essential) of Positive_regulation (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
1) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.60
Calcium influx into the postsynaptic membrane is an essential process in the induction of LTP [54], and this enhanced calcium levels in the postsynaptic neurons activate several protein kinases including the CaMKII, which plays a pivotal role in the induction of LTP [38,55,56].
Positive_regulation (process) of Positive_regulation (induction) of LTP in postsynaptic membrane associated with long-term potentiation
2) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.89
We found that P42/P44 MAPK inhibitors, PD98059 and U0126, suppressed the induction of cingulate LTP that was induced by presynaptic stimulation with postsynaptic depolarization (the pairing protocol).
Positive_regulation (induced) of Positive_regulation (induction) of LTP associated with long-term potentiation
3) Confidence 0.51 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2245920 Disease Relevance 0.07 Pain Relevance 0.72
Taken together, these results indicate that the activation of ERK in LTP induction is not dependent on specific induction paradigms.


Positive_regulation (activation) of Positive_regulation (induction) of LTP associated with long-term potentiation
4) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.63
The role of MAPK cascade in the induction of cingulate LTP has been documented in a previous study [14], which showed that activation of MAPK including ERK, JNK and p38 is critical for the induction of cingulate LTP.
Positive_regulation (critical) of Positive_regulation (induction) of LTP associated with long-term potentiation
5) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.55
Remarkably, (+/-) administration of tianeptine after the stress rapidly overcame the block of LTP induction without affecting baseline excitatory transmission.
Positive_regulation (overcame) of Positive_regulation (induction) of LTP associated with stress and long-term potentiation
6) Confidence 0.40 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978839 Disease Relevance 0.42 Pain Relevance 0.59
In contrast, LTP induction was augmented after chronic morphine infusion for 72 h.
Positive_regulation (augmented) of Positive_regulation (induction) of LTP associated with long-term potentiation and morphine
7) Confidence 0.40 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11701207 Disease Relevance 0 Pain Relevance 1.41
The probability of inducing LTP on a particular occasion was greatly increased by iontophoresis of bicuculline at the recording site during the tetanus (from 20 to 55% judged by a change in peak amplitude).
Positive_regulation (increased) of Positive_regulation (inducing) of LTP associated with anaerobic bacterial infections
8) Confidence 0.40 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9704999 Disease Relevance 0.17 Pain Relevance 0.23
Under urethane anesthesia, we have previously observed Pb-induced increases in the threshold for LTP induction.
Positive_regulation (increases) of Positive_regulation (induction) of LTP associated with anesthesia and long-term potentiation
9) Confidence 0.40 Published 1998 Journal Brain Res. Section Abstract Doc Link 9602098 Disease Relevance 0.09 Pain Relevance 0.50
The most straightforward interpretation of our results is that LTP induced by glutamate iontophoresis on dendrites of CA1 pyramidal neurons is mediated largely by postsynaptic changes.
Positive_regulation (mediated) of in pyramidal neurons Positive_regulation (induced) of LTP in dendrites associated with glutamate and pyramidal cell
10) Confidence 0.40 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8734590 Disease Relevance 0 Pain Relevance 0.52
Using single-cell recording techniques, we have tested the hypothesis that endogenous opioids are required for mossy fiber LTP induction.
Positive_regulation (required) of Positive_regulation (induction) of LTP in mossy fiber associated with endogenous opioid and long-term potentiation
11) Confidence 0.40 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642409 Disease Relevance 0 Pain Relevance 1.37
These results suggest that neuron activities in the ipsilateral BLA are partly required for the induction of LTP in the dentate gyrus in vivo.
Positive_regulation (required) of Positive_regulation (induction) of LTP in dentate gyrus associated with long-term potentiation and amygdala
12) Confidence 0.40 Published 1995 Journal Brain Res. Section Abstract Doc Link 7743229 Disease Relevance 0 Pain Relevance 0.70
While the induction of LTP in general requires activation of postsynaptic glutamate receptors, the expression of LTP can be mediated by postsynaptic mechanisms and/or presynaptic enhancement of glutamate release.
Positive_regulation (requires) of Positive_regulation (induction) of LTP associated with glutamate, glutamate receptor and long-term potentiation
13) Confidence 0.39 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.41 Pain Relevance 0.84
After isoflurane anesthesia before euthanasia capsaicin caused a TRPV1-mediated increase in the magnitude of LA-LTP.
Positive_regulation (caused) of Positive_regulation (increase) of LTP associated with anesthesia, qutenza, long-term potentiation, isoflurane and amygdala
14) Confidence 0.39 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.53
As shown in Fig. 7A, capsaicin caused a significant enhancement of the magnitude of EC-induced LA-LTP in the isoflurane group (control: 128.1±4.1% [n?
Positive_regulation (enhancement) of Positive_regulation (induced) of LTP associated with qutenza, isoflurane, long-term potentiation and amygdala
15) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.07 Pain Relevance 1.71
This suggests that opioid receptors are involved in a mechanism of LTP induction that is specific to mossy fiber synapses, and that endogenous opioid receptors are involved in a mechanism of LTP induction that is specific to mossy fiber synapses, and that endogenous opioid peptides, presumably released as a result of mossy fiber stimulation, may be necessary for the induction of mossy fiber LTP.
Spec (may) Positive_regulation (necessary) of Positive_regulation (induction) of LTP in mossy fiber associated with endogenous opioid, long-term potentiation and opioid receptor
16) Confidence 0.39 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1660336 Disease Relevance 0 Pain Relevance 1.14
LTP produced by nerve transection could not be further potentiated by electrical tetanic stimulation, while LTP induced by single electrical tetanic stimulation could be further potentiated by transection of the sciatic nerve.
Positive_regulation (potentiated) of Positive_regulation (induced) of LTP in nerve associated with sciatic nerve and long-term potentiation
17) Confidence 0.38 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15497039 Disease Relevance 0.32 Pain Relevance 1.40
Calcium influx into the postsynaptic membrane is an essential process in the induction of LTP [54], and this enhanced calcium levels in the postsynaptic neurons activate several protein kinases including the CaMKII, which plays a pivotal role in the induction of LTP [38,55,56].
Positive_regulation (activate) of in postsynaptic membrane Positive_regulation (induction) of LTP in neurons associated with long-term potentiation
18) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.91
These results suggest that the activation of MAPK including ERK, JNK and p38, is critical for the induction of LTP in the ACC.


Positive_regulation (critical) of Positive_regulation (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
19) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.39
This result indicates that blockade of transcription and translation selectively inhibited the early-phase LTP without affecting LTP induction.
Neg (without) Positive_regulation (affecting) of Positive_regulation (induction) of LTP associated with long-term potentiation
20) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.61

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