INT130363

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.99
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
endothelial cells 1
PSC 1
platelets 1
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 136 90.88 High High
anesthesia 8 83.44 Quite High
isoflurane 10 83.00 Quite High
Bioavailability 2 81.28 Quite High
fibrosis 3 81.04 Quite High
Chronic pancreatitis 3 78.80 Quite High
agonist 16 63.84 Quite High
addiction 1 50.00 Quite Low
Glutamate receptor 2 29.40 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 92 99.72 Very High Very High Very High
Cancer 713 99.64 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.08 Very High Very High Very High
Targeted Disruption 23 95.84 Very High Very High Very High
Corneal Neovascularization 23 95.52 Very High Very High Very High
Injury 5 95.12 Very High Very High Very High
Melanoma 38 92.40 High High
INFLAMMATION 154 90.88 High High
Hyperplasia 1 87.68 High High
Fibrosis 7 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 activation unless there was an ongoing supply of TSP-1 as may occur if there is continued release of TSP-1 from additional platelets.
Localization (release) of TSP-1 in platelets
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
The eluates were analyzed for the presence of proteins containing free thiols by MPB labeling and TSP-1 by immunoblotting (Fig. 3C).
Localization (labeling) of TSP-1
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
In cultured PSC, these transcripts were also increased in response to serum and increases in mRNA were reflected by the secretion of TSP-1 and TSP-2 proteins by PSC into culture media.
Localization (secretion) of TSP-1 in PSC associated with primary sclerosing cholangitis
3) Confidence 0.74 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.37 Pain Relevance 0.24
Neutralization of thrombospondin-1 restores tumor growth in PPAR?
Localization (Neutralization) of thrombospondin-1 associated with cancer
4) Confidence 0.54 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1800345 Disease Relevance 1.20 Pain Relevance 0.21
Thrombospondin-1 (TSP1) is a secreted protein that forms a 450-kDa homotrimer.
Localization (secreted) of Thrombospondin-1
5) Confidence 0.52 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.79 Pain Relevance 0.03
For neutralizing antibody experiments the A4.1 anti-TSP-1 monoclonal antibody (Lab Vision, Fremont, CA) (CSVTCG/CD36) or control antibody (IgM) at 50 µg/mouse were administered intraperitoneally daily to PPAR?
Localization (administered) of anti-TSP-1
6) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.83 Pain Relevance 0
Total protein extracts (50 µg) were analyzed on blots incubated with primary mouse monoclonal TSP-1 (Ab-11, Lab Vision, Fremont, CA) and HRP-conjugated secondary antibodies (Amersham Biosciences Corp.
Localization (monoclonal) of TSP-1
7) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.35 Pain Relevance 0.24
THBS1 is released by
Localization (released) of THBS1
8) Confidence 0.45 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.09 Pain Relevance 0
The antiangiogenic effects of THBS1 appear to be localized to a peptide sequence containing the type I repeats domain, which binds CD36 on ECs [37].
Localization (localized) of THBS1
9) Confidence 0.42 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.26 Pain Relevance 0.04
endothelial cells also secrete THBS1 or their function is modulated by THBS.
Localization (secrete) of THBS1 in endothelial cells
10) Confidence 0.40 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.10 Pain Relevance 0

General Comments

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