INT130364

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 7.73
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
plasma 1
pancreas 1
bone marrow 1
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 97.28 Very High Very High Very High
Inflammation 136 94.32 High High
cytokine 20 91.08 High High
agonist 25 86.72 High High
Inflammatory response 15 81.20 Quite High
Chronic pancreatitis 3 76.92 Quite High
chemokine 3 64.20 Quite High
fibrosis 4 63.12 Quite High
addiction 1 62.08 Quite High
dexamethasone 5 54.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 426 99.24 Very High Very High Very High
Melanoma 14 98.68 Very High Very High Very High
Injury 5 96.88 Very High Very High Very High
INFLAMMATION 159 94.32 High High
Primary Sclerosing Cholangitis 6 93.92 High High
Metastasis 25 92.28 High High
Multiple Myeloma 24 89.44 High High
Fibrosis 7 81.32 Quite High
Polyps 2 79.20 Quite High
Pancreatitis 3 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used the Min mouse model to determine if sulindac sulfide would increase Egr-1 and TSP-1 in vivo, because this model is widely used to study the effects of NSAIDs on tumor formation.
Spec (determine) Positive_regulation (increase) of TSP-1 associated with cancer and cinod
1) Confidence 0.62 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.59 Pain Relevance 0.38
Furthermore, the induction of TSP-1 by sulindac sulfide was blocked by Egr-1 siRNA.
Positive_regulation (induction) of TSP-1
2) Confidence 0.62 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.63 Pain Relevance 0.38
1 complex peptides VLAL and LSKL can inhibit TSP-1-mediated activation of TGF-?
Positive_regulation (activation) of TSP-1-mediated
3) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
KO mice contained high levels of TSP-1 protein (Figure 5A), despite that these tumor cells do not express TSP-1 [29].
Positive_regulation (levels) of TSP-1 associated with cancer
4) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.32 Pain Relevance 0.17
In fact, TSP-1 was elevated in the plasma and tumor tissue of PPAR?
Positive_regulation (elevated) of TSP-1 in plasma associated with cancer
5) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.53 Pain Relevance 0.26
The mRNA transcripts for TSP-1 and TSP-2 were increased, 16-fold and 87-fold respectively, in the pancreas in response to repetitive injury.
Positive_regulation (increased) of TSP-1 in pancreas associated with injury
6) Confidence 0.19 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.40 Pain Relevance 0.23
as a consequence of an increased production of anti-angiogenic factors TSP-1
Positive_regulation (factors) of TSP-1
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.37 Pain Relevance 0.49
Based on a significant decrease of VEGF and hepatocyte growth factor levels, and a significant increase in TSP-1 thrombospondin-1 concentrations in the bone marrow plasma of patients who achieved complete or very good partial response versus those who had partial or no response, they concluded that a reduction in the rate of angiogenesis had occurred.
Positive_regulation (increase) of TSP-1 thrombospondin-1 in bone marrow
8) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.89 Pain Relevance 0.05

General Comments

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