INT130372

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.93
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
Anatomy Link Frequency
endothelial cells 3
a band 1
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 10 87.48 High High
Migraine 1 85.16 High High
anesthesia 2 72.24 Quite High
Regional anesthesia 2 67.28 Quite High
Angina 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 53 98.40 Very High Very High Very High
Headache 5 87.48 High High
Cardiovascular Disease 11 80.92 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 78.60 Quite High
Hepatitis 2 78.28 Quite High
Pregnancy-induced Hypertension 2 77.84 Quite High
Eclampsia 6 75.84 Quite High
Diabetes Mellitus 11 68.72 Quite High
Heart Disease 2 68.32 Quite High
Hypertension 25 67.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the presence of PDE5 mRNA and protein in human arteries.
Transcription (presence) of PDE5
1) Confidence 0.72 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16182282 Disease Relevance 0.31 Pain Relevance 0.26
CONCLUSIONS: Long-term NO stimulation modulated PDE3 and PDE5 mRNA expression in endothelial cells.
Transcription (expression) of PDE5 in endothelial cells
2) Confidence 0.70 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
More physicians are treating ED, especially in the primary care setting, including minimal patient work-up and prescription of PDE5i due to their proven efficacy and safety profile.
Transcription (prescription) of PDE5i associated with reprotox - general 2
3) Confidence 0.69 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699643 Disease Relevance 1.31 Pain Relevance 0
RESULTS: This study shows the expression of PDE2A, PDE3B, and PDE5A mRNA and PDE3B and PDE5A protein in human cerebral endothelial cells.
Transcription (expression) of PDE5A in endothelial cells
4) Confidence 0.67 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
RESULTS: This study shows the expression of PDE2A, PDE3B, and PDE5A mRNA and PDE3B and PDE5A protein in human cerebral endothelial cells.
Transcription (expression) of PDE5A protein in endothelial cells
5) Confidence 0.67 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
RT-PCR detection of Phosphodiesterase-5 mRNA
Transcription (detection) of Phosphodiesterase-5
6) Confidence 0.67 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0.31 Pain Relevance 0.14
Phosphodiesterase-5 mRNA is present in chorionic plate arterial rings as demonstrated by RT-PCR. cDNA prepared from RNA extracted from homogenized chorionic plate arterial rings, and amplified by PCR using specific primers for the phosphodiesterase-5 gene, and electrophoresed on 1% agarose, demonstrated a band for phosphodiesterase-5 (Figure 2 Panel A).
Transcription (present) of Phosphodiesterase-5 in a band
7) Confidence 0.52 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0 Pain Relevance 0

General Comments

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