INT130375

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.62
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria3) protein complex (Gria3)
Gria3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 1 99.70 Very High Very High Very High
tetrodotoxin 1 97.60 Very High Very High Very High
depression 1 96.80 Very High Very High Very High
Spinal cord 4 89.32 High High
IPN 1 86.64 High High
Glutamate receptor 2 86.60 High High
Dorsal horn neuron 1 83.28 Quite High
long-term potentiation 7 77.60 Quite High
Hyperalgesia 1 76.44 Quite High
Lasting pain 1 75.44 Quite High
Disease Link Frequency Relevance Heat
Depression 1 96.80 Very High Very High Very High
Inflammatory Pain 1 86.64 High High
Hyperalgesia 1 76.44 Quite High
Pain 1 75.44 Quite High
INFLAMMATION 3 75.00 Quite High
Nervous System Injury 13 68.08 Quite High
Injury 3 67.44 Quite High
Carpal Tunnel Syndrome 4 23.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant with the decrease in NSF, GluR2 and GluR3 were decreased and GluR1 was conversely increased in the PSD fraction 24 h after CFA injection.
Negative_regulation (decrease) of GluR3
1) Confidence 0.57 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18598260 Disease Relevance 0.52 Pain Relevance 0.75
While they do report significant decreases in GluR2 and GluR3 subunits, there are no significant changes in GluR1 expression (see Supplementary Material Figure 4a; Wright et al., 2008).
Negative_regulation (decreases) of GluR3
2) Confidence 0.15 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0.10 Pain Relevance 0.13
The blockade of action potential significantly decreased GLuR2-3, NR1and NR2A mRNAs in the ipsilateral facial nuclei.
Negative_regulation (decreased) of GLuR2-3 associated with action potential
3) Confidence 0.04 Published 2005 Journal Neuroscience Section Abstract Doc Link 16182453 Disease Relevance 0 Pain Relevance 0.22

General Comments

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