INT130391

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.70
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AKR1C3) intracellular (AKR1C3) cytoplasm (AKR1C3)
AKR1C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 99.56 Very High Very High Very High
diclofenac 1 89.28 High High
antagonist 1 46.60 Quite Low
Potency 2 45.56 Quite Low
Analgesic 1 13.12 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 2 98.60 Very High Very High Very High
Cancer 124 94.76 High High
Metastasis 56 94.32 High High
Prostate Cancer 55 83.56 Quite High
INFLAMMATION 2 82.08 Quite High
Small Cell Lung Cancer 7 76.24 Quite High
Breast Cancer 25 75.00 Quite High
Carcinoma 8 52.24 Quite High
Adhesions 14 47.84 Quite Low
Disease 5 37.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in contrast to their findings, transcripts for AKR1C3, SRD5A1, HSD3B2, AKR1C2, AKR1C1 are not consistently upregulated in the metastatic samples in our study.
Neg (not) Positive_regulation (upregulated) of AKR1C3
1) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.68 Pain Relevance 0
In order to obtain more information about the structure-activity relationship and to identify new leads, a series of compounds designed on the basis of NSAIDs were synthesized and screened on AKR1C3.
Positive_regulation (screened) of AKR1C3 associated with cinod
2) Confidence 0.49 Published 2005 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 16183274 Disease Relevance 0.16 Pain Relevance 0.47
DHP requires the actions of AKR1C1-AKR1C3 (3?
Positive_regulation (requires) of AKR1C3
3) Confidence 0.48 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.69 Pain Relevance 0
Of the 55 genes upregulated more than fourfold in oxoplatin-treated H526 cells only three genes, namely, HIST2H2BE, PNUTL2, and AKR1C3, were in common with those genes upregulated in cisplatin-treated cells (the 27 genes exhibiting the strongest increases in expression triggered by oxoplatin are shown in Table 1).
Positive_regulation (upregulated) of AKR1C3
4) Confidence 0.11 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.17 Pain Relevance 0

General Comments

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