INT130392

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 7.34
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 11 98.40 Very High Very High Very High
rheumatoid arthritis 45 97.80 Very High Very High Very High
Inflammation 15 96.60 Very High Very High Very High
Pain 5 93.84 High High
Chronic pancreatitis 2 93.68 High High
chemokine 1 89.28 High High
COX2 1 85.36 High High
cINOD 2 84.24 Quite High
cytokine 3 81.20 Quite High
alcohol 1 78.80 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Thrombocytopenia 1 99.96 Very High Very High Very High
Pancreatic Cancer 22 99.86 Very High Very High Very High
Hepatocellular Cancer 4 99.34 Very High Very High Very High
Hemolytic Anemia 1 99.22 Very High Very High Very High
Low Back Pain 11 98.40 Very High Very High Very High
Rheumatoid Arthritis 46 97.80 Very High Very High Very High
Cancer 42 97.08 Very High Very High Very High
INFLAMMATION 17 96.60 Very High Very High Very High
Colon Cancer 5 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coculturing of a human hepatoma cell line, Hep3B, with PC cells-induced production of fucosylated haptoglobin, suggesting that PC produces a factor that induces the production of fucosylated haptoglobin.
Positive_regulation (induced) of Gene_expression (production) of haptoglobin associated with pancreatic cancer and hepatocellular cancer
1) Confidence 0.69 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.73 Pain Relevance 0.14
Coculturing of a human hepatoma cell line, Hep3B, with PC cells-induced production of fucosylated haptoglobin, suggesting that PC produces a factor that induces the production of fucosylated haptoglobin.
Positive_regulation (induces) of Gene_expression (production) of haptoglobin associated with pancreatic cancer and hepatocellular cancer
2) Confidence 0.50 Published 2008 Journal Proteomics Section Abstract Doc Link 18646007 Disease Relevance 1.60 Pain Relevance 0.14
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Positive_regulation (elevated) of Gene_expression (level) of haptoglobin associated with hemolytic anemia and thrombocytopenia
3) Confidence 0.39 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.56 Pain Relevance 0.09
Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients.
Positive_regulation (Increased) of Gene_expression (expression) of haptoglobin precursor associated with spinal inflammation
4) Confidence 0.34 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17434140 Disease Relevance 0.91 Pain Relevance 0.96
For example, IL-6 initiates the acute-phase response inducing the hepatic synthesis of acute phase proteins including C-reactive protein (CRP), serum amyloid, haptoglobin, and fibrinogen among others (Cronstein 2007).
Positive_regulation (inducing) of Gene_expression (synthesis) of haptoglobin associated with alzheimer's dementia
5) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 1.18 Pain Relevance 0.41
Finally, VSP inhibition–induced BP elevation will dissipate with discontinuation of VSP inhibition.
Positive_regulation (induced) of Gene_expression (elevation) of BP
6) Confidence 0.05 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2864290 Disease Relevance 0.36 Pain Relevance 0.17
SULT1C1, SULT1C2, SULT1C3, and SULT1B1 showed similar saturation binding curves, reaching saturation at about 100 ?
Positive_regulation (saturation) of Gene_expression (curves) of binding
7) Confidence 0.04 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0

General Comments

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