INT130400

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ID1) cytoplasm (ID1)
Anatomy Link Frequency
A2780 2
ID1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 75.80 Quite High
psoriasis 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 2 98.88 Very High Very High Very High
Ovarian Cancer 2 97.28 Very High Very High Very High
Psoriasis 10 90.96 High High
Stomach Cancer 6 86.88 High High
Cancer 51 78.32 Quite High
Colorectal Cancer 2 73.08 Quite High
Death 1 45.44 Quite Low
Leukemia 2 44.08 Quite Low
Disease 2 42.36 Quite Low
Apoptosis 16 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Id-1 expression level was decreased dose-dependently by sulindac sulfide.
Negative_regulation (decreased) of Gene_expression (expression) of Id-1
1) Confidence 0.59 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16184548 Disease Relevance 0.53 Pain Relevance 0.08
This correlates well with our results on repressed ID-1 expression, since both BMP-2 and -4 up-regulate ID-1 [64,65].
Negative_regulation (repressed) of Gene_expression (expression) of ID-1
2) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0
The cell cycle blockade and differentiation caused by such a drug, trichostatin A, caused decreased levels of ID-1 consistent with cell cycle senescence and differentiation of A2780 ovarian cancer cells [17].
Negative_regulation (decreased) of Gene_expression (levels) of ID-1 in A2780 associated with aging and ovarian cancer
3) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.29 Pain Relevance 0

General Comments

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