INT13041

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.92
Pain Relevance 7.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)
Anatomy Link Frequency
substantia nigra 2
trigeminal ganglion 1
artery 1
blood vessel smooth muscles 1
APtN 1
Htr1b (Rattus norvegicus)
Htr1b - G861C (1)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Sumatriptan 52 99.96 Very High Very High Very High
Substantia nigra 6 99.68 Very High Very High Very High
Triptan 11 99.38 Very High Very High Very High
Migraine 13 99.22 Very High Very High Very High
agonist 31 99.12 Very High Very High Very High
Enkephalin 4 98.84 Very High Very High Very High
Serotonin 22 98.68 Very High Very High Very High
Opioid 13 98.62 Very High Very High Very High
fluoxetine 14 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.92 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 28 99.60 Very High Very High Very High
Headache 13 99.22 Very High Very High Very High
Cluster Headache 4 98.86 Very High Very High Very High
Ganglion Cysts 7 96.12 Very High Very High Very High
Urological Neuroanatomy 55 93.12 High High
Anxiety Disorder 4 91.88 High High
Obsessive-compulsive Disorder 3 91.68 High High
Adhesions 1 87.04 High High
Aggression 5 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-treatment with the antimigraine drugs dihydroergotamine and sumatriptan, two drugs that bind with high affinity to 5-HT1B/1D receptors, markedly attenuated plasma protein extravasation induced by electrical trigeminal ganglion stimulation.
5-HT1B Binding (bind) of in trigeminal ganglion associated with ganglion cysts, cluster headache, sumatriptan and trigeminal ganglion
1) Confidence 0.47 Published 1991 Journal Cephalalgia Section Abstract Doc Link 1660351 Disease Relevance 0.51 Pain Relevance 0.64
These results indicate that the antinociceptive effects of opioid or serotonergic agonists microinjected into the APtN depend on drug interaction with local mu or 5-HT1B receptors, respectively.
5-HT1B Binding (interaction) of in APtN associated with agonist, opioid and antinociceptive
2) Confidence 0.47 Published 1997 Journal Brain Res. Section Abstract Doc Link 9200507 Disease Relevance 0 Pain Relevance 1.11
Moreover, the increases in 5-HT1B/1D binding in the substantia nigra and in the shell of the nucleus accumbens reinforce the view of an implication of this receptor subtype in motor functions.
5-HT1B Binding (binding) of in substantia nigra associated with nucleus accumbens and substantia nigra
3) Confidence 0.47 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630549 Disease Relevance 0 Pain Relevance 0.43
A selective 5-HT 1B receptor antagonist (GR 55562; 1 mg/kg), but not a 5-HT2 receptor antagonist (ritanserin; 2 mg/kg, i.p.), counteracted the effects of methamphetamine and fluoxetine on the motor activation induced by methylphenidate.
5-HT 1B Binding (counteracted) of associated with antagonist and fluoxetine
4) Confidence 0.36 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17487226 Disease Relevance 0.10 Pain Relevance 0.57
The present findings have demonstrated that sumatriptan, acting via 5-HT1B and 5-HT1D receptors, produces presynaptic disinhibition, similar to that previously observed for ?
5-HT1B Binding (acting) of associated with sumatriptan
5) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.53 Pain Relevance 1.73
Similarly, pretreatment of rats with GR 127935 (5 mg/kg i.p.), an antagonist with high affinity for 5-HT1B/D receptors, blocked the reduction of hippocampal 5-HT synthesis following the 5-HT receptor agonist TFMPP (3 mg/kg s.c.) without affecting the reduction of hippocampal 5-HT synthesis by either fluoxetine or paroxetine.
5-HT1B Binding (affinity) of associated with antagonist, agonist and fluoxetine
6) Confidence 0.36 Published 1999 Journal Synapse Section Abstract Doc Link 10025679 Disease Relevance 0 Pain Relevance 0.66
The present results suggest a preferential association between 5-HT1B/1D receptors and the striatonigral neurons containing substance P, as indicated by the striatal distribution of these receptors and their selective increases in the substantia nigra after severe 5-HT deprivation.
5-HT1B Binding (association) of in substantia nigra associated with substantia nigra and substance p
7) Confidence 0.36 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630549 Disease Relevance 0 Pain Relevance 0.43
In addition we did not find evidence to suggest an association between HTR1B and perfectionism in this sample of ADHD families.
HTR1B Binding (association) of associated with attention deficit hyperactivity disorder
8) Confidence 0.12 Published 2007 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 16958036 Disease Relevance 0.97 Pain Relevance 0.16
There were no significant associations between fluoxetine response and TPH1 (A218C) (-6525 A>G) (-5806 G>T), HTR1B (G861C) and HTR2C (G68C) genotype groups.
HTR1B (G861C) Neg (no) Binding (associations) of
9) Confidence 0.11 Published 2010 Journal Psychiatr. Genet. Section Body Doc Link 20010449 Disease Relevance 0.07 Pain Relevance 0
Evidence for an association between the HTR1B gene and ADHD as a qualitative diagnosis, or the inattentive and hyperactive-impulsive quantitative traits was not supported by either TDT single marker analysis or haplotype analysis.
HTR1B Binding (association) of associated with attention deficit hyperactivity disorder
10) Confidence 0.09 Published 2007 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 16958036 Disease Relevance 0.99 Pain Relevance 0.18
The objectives of this study were to: (i) expand our original investigation of the relationship between the HTR1B receptor gene and attention deficit/hyperactivity and; (ii) to investigate a possible association of obsessive behaviors/perfectionism and the HTR1B gene in a sample of 203 families with an ADHD proband.
HTR1B Binding (association) of associated with attention deficit hyperactivity disorder
11) Confidence 0.09 Published 2007 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 16958036 Disease Relevance 1.07 Pain Relevance 0.20
Anti-migraine triptan drugs block vasodilatation by binding to 5-HT1B/1D receptors localized on the peripheral sensory terminals and dural blood vessel smooth muscles.
5-HT1B Binding (binding) of in blood vessel smooth muscles associated with migraine, triptan and increased venous pressure under development
12) Confidence 0.09 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11422450 Disease Relevance 0.68 Pain Relevance 0.95
Methiothepin was the only compound that antagonized both the opossum kidney cell and CHL fibroblast 5-HT1B receptor-mediated responses although the antagonist effect was more pronounced in CHL fibroblasts.
CHL fibroblast 5-HT1B Binding (antagonized) of in fibroblasts associated with antagonist
13) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932206 Disease Relevance 0 Pain Relevance 0.46
Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery.
5-hydroxytryptamine1B-like Binding (characterization) of in artery
14) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9353382 Disease Relevance 0 Pain Relevance 0.43

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