INT13042

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 4.65
Pain Relevance 6.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INA)
Anatomy Link Frequency
fibroblasts 6
myocytes 2
heart 2
cardiac myocytes 1
smooth muscles 1
INA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 357 100.00 Very High Very High Very High
sodium channel 17 100.00 Very High Very High Very High
lidocaine 28 99.78 Very High Very High Very High
local anesthetic 7 99.32 Very High Very High Very High
Action potential 90 98.60 Very High Very High Very High
Nav1.6 4 96.48 Very High Very High Very High
agonist 5 93.76 High High
Bioavailability 1 77.32 Quite High
Neuronal excitability 1 76.16 Quite High
headache 2 69.24 Quite High
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 11 99.86 Very High Very High Very High
Disease 11 99.22 Very High Very High Very High
Cancer 8 98.84 Very High Very High Very High
Myocardial Infarction 76 98.08 Very High Very High Very High
Leiomyosarcoma 2 97.44 Very High Very High Very High
Apoptosis 16 93.64 High High
Adenoma 3 92.60 High High
Injury 11 92.36 High High
Neuroblastoma 2 91.00 High High
Ganglion Cysts 3 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that INa is expressed in VSMCs grown from human aortic (90%; n = 48) and pulmonary (44%; n = 16) arteries and in the human aortic cell line HAVSMC (94%; n = 27).
Gene_expression (expressed) of INa
1) Confidence 0.78 Published 2000 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 10989746 Disease Relevance 0.19 Pain Relevance 0.14
The expression of INa(f) was dependent on the concentration of fetal bovine serum (FBS) in the culture medium.
Gene_expression (expression) of INa
2) Confidence 0.75 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7977692 Disease Relevance 0.22 Pain Relevance 0.07
It is well recognized that INa channels expressed in cardiomyocytes (mainly encoded by NaV1.5) play an important role in controlling excitation-contraction and impulse conduction in the hearts.
Gene_expression (expressed) of INa in hearts
3) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.19 Pain Relevance 0.13
In the present study, we found that INa was expressed in most (61%) human cardiac fibroblasts (Fig. 1).
Gene_expression (expressed) of INa in fibroblasts
4) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.16 Pain Relevance 0.24
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (expressed) of INa in fibroblasts associated with tetrodotoxin
5) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10
Although lidocaine block of cardiac Na+ current (INa) has been extensively studied in animal tissues, very little is known about its actions on human cardiac INa.
Gene_expression (actions) of INa in animal tissues associated with lidocaine
6) Confidence 0.68 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8383745 Disease Relevance 0 Pain Relevance 0.61
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (expressed) of INa in fibroblasts associated with tetrodotoxin
7) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (expressed) of INa in fibroblasts associated with tetrodotoxin
8) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10
Some properties of INa.TTXR in human cardiac fibroblasts are not identical to those of INa in human cardiomyocytes [27], [37], [38], e.g. more positive V0.5s of activation (?
Gene_expression (properties) of INa in fibroblasts
9) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.12 Pain Relevance 0.27
We currently investigate whether INa is expressed in vascular smooth muscles cells (VSMCs) isolated from either healthy or diseased (atheromatous) arteries in human and, in parallel, in pig, rabbit and rat.
Gene_expression (expressed) of INa in smooth muscles
10) Confidence 0.60 Published 2000 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 10989746 Disease Relevance 0.17 Pain Relevance 0.09
One of limitations of the present study was that ion channels, BKCa, Ito, IKir and ICl.vol, and INa.TTX, and INa.TTXR, were heterogeneously expressed within the same species of cultured human cardiac fibroblasts.
Gene_expression (expressed) of INa in fibroblasts associated with tetrodotoxin
11) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0.13 Pain Relevance 0.10
The inactivation process of INa.TTX was slower than that of INa.TTXR (Fig. 7B, n?
Gene_expression (process) of INa associated with tetrodotoxin
12) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 1.11
INa was also detected in pig coronary (60%; n = 25) and rabbit aortic (47%; n = 15) VSMCs, but not in rat aortic myocytes (n = 30).
Neg (not) Gene_expression (detected) of INa in myocytes
13) Confidence 0.53 Published 2000 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 10989746 Disease Relevance 0.25 Pain Relevance 0.15
Primary cultured human coronary myocytes, derived from patients with end-stage heart failure (NYHA, classes III and IV) caused by an ischemic disease and undergoing heart transplantation, express a voltage-gated tetrodotoxin-sensitive sodium current (INa).
Gene_expression (express) of INa in heart associated with tetrodotoxin, disease and myocardial infarction
14) Confidence 0.53 Published 2000 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 10989746 Disease Relevance 0.20 Pain Relevance 0.10
In voltage-clamp experiments on frog myelinated fibres it has been established that the increase in Ca2+ concentration from 2 to 20 mM does not effect the use-dependent (cumulative) inhibition of sodium channels (INa) produced by the tertiary local anesthetics (lidocaine, tetracaine, etidocaine) and the quaternary antiarrhythmic drug N-propyl ajmaline (NPA).
Gene_expression (produced) of INa associated with sodium channel, lidocaine and local anesthetic
15) Confidence 0.52 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2410054 Disease Relevance 0 Pain Relevance 0.51
In conclusion, human coronary myocytes in culture can express an atypical tetrodotoxin-sensitive INa with a large sustained component, which is expected to contribute to massive Na+ influx into these cells.
Gene_expression (express) of INa in myocytes associated with tetrodotoxin
16) Confidence 0.51 Published 1997 Journal Circ. Res. Section Abstract Doc Link 9048658 Disease Relevance 0.06 Pain Relevance 0.48
Phenotypic modulation of the expression of this INa may be related to cell dedifferentiation and proliferation.
Gene_expression (expression) of INa
17) Confidence 0.51 Published 1997 Journal Circ. Res. Section Abstract Doc Link 9048658 Disease Relevance 0 Pain Relevance 0.45
Internal application of QX-314, a permanently charged lidocaine analogue, produced a single exponential block of INa with a very slow onset rate.
Gene_expression (produced) of INa in Internal associated with lidocaine
18) Confidence 0.49 Published 1991 Journal Circ. Res. Section Abstract Doc Link 1660356 Disease Relevance 0 Pain Relevance 0.26
Two INa types with different time-, voltage-dependent properties and tetrodotoxin (TTX) sensitivities were expressed in DM and CM.
Gene_expression (expressed) of INa associated with tetrodotoxin
19) Confidence 0.45 Published 1997 Journal Glia Section Abstract Doc Link 9034832 Disease Relevance 0.17 Pain Relevance 0.33
Astrocytoma cells expressing INa could be induced to generate slow action potential-like responses (spikes) by current injections.
Gene_expression (expressing) of INa in spikes associated with anaplastic astrocytoma and action potential
20) Confidence 0.44 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9582244 Disease Relevance 0.81 Pain Relevance 0.12

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