INT130421

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.57
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MSR1) plasma membrane (MSR1)
Anatomy Link Frequency
macrophages 2
MSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 3 66.48 Quite High
Cannabinoid 15 50.00 Quite Low
Angina 7 50.00 Quite Low
antagonist 4 50.00 Quite Low
Endocannabinoid 13 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Nucleus accumbens 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 25 99.76 Very High Very High Very High
Disorder Of Lipid Metabolism 18 84.16 Quite High
Hypoxia 14 72.96 Quite High
Atherosclerosis 39 62.00 Quite High
Cv General 3 Under Development 7 50.00 Quite Low
Thrombosis 3 50.00 Quite Low
Attention Deficit Hyperactivity Disorder 18 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that LIGHT enhanced lipid accumulation in oxLDL-stimulated THP-1 macrophages, possibly through upregulation of class A scavenger receptor (SR-A).
Spec (possibly) Positive_regulation (upregulation) of SR-A in macrophages
1) Confidence 0.67 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Finally, the LIGHT-mediated enhancement of SR-A and TF expression appears to involve nuclear factor-kappaB activation.
Positive_regulation (enhancement) of SR-A
2) Confidence 0.49 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
We also showed that LIGHT enhanced lipid accumulation in oxLDL-stimulated THP-1 macrophages, possibly through upregulation of class A scavenger receptor (SR-A).
Spec (possibly) Positive_regulation (upregulation) of scavenger receptor in macrophages
3) Confidence 0.15 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
The SR-BIII isoform is probably generated by the use of an alternative splice acceptor site in intron 11 and encodes a unique intracellular C-terminal of the receptor.
Positive_regulation (generated) of SR-BIII isoform
4) Confidence 0.09 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.57 Pain Relevance 0.03
SR141716A was generated and kindly donated by Solvay Pharmaceuticals (Weesp, The Netherlands), whereas WIN55,212-2 was purchased from Tocris Biosciences (Bristol, United Kingdom).
Positive_regulation (generated) of SR141716A
5) Confidence 0.01 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1915592 Disease Relevance 0 Pain Relevance 0

General Comments

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