INT130424

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 16.31
Pain Relevance 13.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Adcy1) plasma membrane (Adcy1) nucleus (Adcy1)
Anatomy Link Frequency
muscle 3
body 3
nerve 2
ACC neurons 1
synapses 1
Adcy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 118 100.00 Very High Very High Very High
Eae 32 99.96 Very High Very High Very High
Anterior cingulate cortex 512 99.84 Very High Very High Very High
Inflammation 194 99.84 Very High Very High Very High
Pain 437 99.72 Very High Very High Very High
long-term potentiation 195 98.96 Very High Very High Very High
Neuropathic pain 53 98.96 Very High Very High Very High
IPN 86 98.04 Very High Very High Very High
Pyramidal cell 39 97.12 Very High Very High Very High
nMDA receptor 184 96.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 427 100.00 Very High Very High Very High
Pain 300 100.00 Very High Very High Very High
Inflammatory Pain 116 99.96 Very High Very High Very High
INFLAMMATION 194 99.84 Very High Very High Very High
Myalgia 261 99.72 Very High Very High Very High
Body Weight 45 99.62 Very High Very High Very High
Nervous System Injury 34 99.42 Very High Very High Very High
Neuropathic Pain 329 98.96 Very High Very High Very High
Nociception 130 98.60 Very High Very High Very High
Injury 84 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraperitoneal injection of AC1 inhibitor
Negative_regulation (inhibitor) of AC1
1) Confidence 0.58 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.47 Pain Relevance 0.45
In ACC synapses with inflammatory pain, inhibition of AC1 and/or AC8 were sufficient to inhibit the long-lasting enhanced presynaptic transmitter release [15].
Negative_regulation (inhibition) of AC1 in synapses associated with eae and anterior cingulate cortex
2) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2639542 Disease Relevance 0.87 Pain Relevance 0.76
Finally, we found that both presynaptic and postsynaptic changes after nerve injury were absent in genetic mice lacking calcium-stimulated adenylyl cyclase 1 (AC1).
Negative_regulation (lacking) of AC1 in nerve associated with nervous system injury
3) Confidence 0.43 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.84 Pain Relevance 0.72
Finally, we found that both presynaptic and postsynaptic changes after nerve injury were absent in genetic mice lacking calcium-stimulated adenylyl cyclase 1 (AC1).
Negative_regulation (lacking) of adenylyl cyclase 1 in nerve associated with nervous system injury
4) Confidence 0.43 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18632948 Disease Relevance 0.84 Pain Relevance 0.72
The total responses were reduced to almost one fourth, indicating that the AC1 inhibitor, at a concentration of 1 mg/kg body weight, is sufficient to block AC1 activity.
Negative_regulation (block) of AC1 in body associated with body weight
5) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.56 Pain Relevance 1.03
The effect of the same AC1 inhibitor was also tested on chronic inflammatory muscle pain.
Negative_regulation (inhibitor) of AC1 in muscle associated with pain, inflammation and myalgia
6) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.52 Pain Relevance 0.99
Effects of deletion of AC1 and AC8 on motor function
Negative_regulation (deletion) of AC1
7) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.70 Pain Relevance 0.88
Inhibition of nociceptive responses in acute and chronic inflammatory muscle pain by the novel AC1 inhibitor
Negative_regulation (inhibitor) of AC1 in muscle associated with nociception, pain, inflammation and myalgia
8) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.39 Pain Relevance 0.81
The total responses were reduced to almost one fourth, indicating that the AC1 inhibitor, at a concentration of 1 mg/kg body weight, is sufficient to block AC1 activity.
Negative_regulation (inhibitor) of AC1 in body associated with body weight
9) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 1.60 Pain Relevance 1.01
Additionally, intra-peritoneal injection of an AC1 inhibitor significantly reduced behavioral responses in both acute persistent and chronic muscle pain.


Negative_regulation (inhibitor) of AC1 in muscle associated with pain and myalgia
10) Confidence 0.43 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1395303 Disease Relevance 1.55 Pain Relevance 1.07
Adult (8–12 weeks) male mice lacking adenylyl cyclase isoforms AC1, AC8 and both AC1 and AC8 [5,16,31] were maintained on a C57BL/6 background and were crossed back at least 12 generations.
Negative_regulation (lacking) of AC1
11) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.67 Pain Relevance 0.54
The novel AC1 inhibitor NB001 was dissolved in 1% DMSO in normal saline and injected into the peritoneal cavity in doses varying from 0.1 to 5 mg/kg body weight in a volume of 10 ?
Negative_regulation (inhibitor) of AC1 in body associated with body weight
12) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395303 Disease Relevance 0.48 Pain Relevance 0.45
We also found the attenuated behavioral sensitization in various chronic pain models in mice lacking AC1 and AC8 [8,43].
Negative_regulation (lacking) of AC1 associated with lasting pain
13) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 1.08 Pain Relevance 1.20
For example, in AC1/8 double knockout mice, chronic pain sensitization was significantly reduced in inflammatory [15] and neuropathic pain model [7,21].
Negative_regulation (reduced) of AC1 associated with targeted disruption, inflammation, lasting pain and neuropathic pain
14) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2639542 Disease Relevance 0.95 Pain Relevance 0.81
The effects of inhibition of AC1 are selective as both basal synaptic responses (mostly mediated by AMPA receptor) and NMDA receptor mediated responses were not affected [47,18].
Negative_regulation (inhibition) of AC1 associated with nmda receptor
15) Confidence 0.24 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.69 Pain Relevance 0.58
Knockdown of AC1 and AC3 with siRNA transfection
Negative_regulation (Knockdown) of AC1
16) Confidence 0.15 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
By using chemical design and biochemical screening, several selective inhibitors of AC1 has been identified.
Negative_regulation (inhibitors) of AC1
17) Confidence 0.14 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.69
Consistently, pharmacological inhibition of AC1 in ACC neurons abolished LTP induced by pairing training (Zhuo, unpublished data).
Negative_regulation (inhibition) of AC1 in ACC neurons associated with long-term potentiation and anterior cingulate cortex
18) Confidence 0.14 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.68
In addition, we show that proteins that interfere with the activity of Gbetagamma subunits (Gbetagamma scavengers) strongly attenuate the acute inhibition of AC-I and -VIII and the superactivation of AC-I, and abolish the superactivation of AC-VIII.
Negative_regulation (inhibition) of AC-I
19) Confidence 0.06 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16186630 Disease Relevance 0.09 Pain Relevance 0.20

General Comments

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