INT130439

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (MARCKS) plasma membrane (MARCKS) cytoplasm (MARCKS)
Anatomy Link Frequency
neurons 2
MARCKS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 65 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
nMDA receptor antagonist 1 96.60 Very High Very High Very High
Spinal cord 1 85.52 High High
Neuropathic pain 1 76.32 Quite High
nMDA receptor 2 74.40 Quite High
Inflammation 4 69.48 Quite High
Central nervous system 10 66.00 Quite High
Pain 1 64.00 Quite High
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 89 88.96 High High
Neuropathic Pain 1 76.32 Quite High
Borna Disease 4 75.00 Quite High
INFLAMMATION 4 69.48 Quite High
Pain 1 64.00 Quite High
Neurological Disease 4 57.64 Quite High
Infection 29 52.92 Quite High
Disease 6 29.12 Quite Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Negative_regulation (pattern) of Phosphorylation (phosphorylation) of MARCKS in neurons associated with kinase c
1) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
Phosphorylation of MARCKS and NADPH-diaphorase activity stimulated by the EP3 agonist were also blocked by H-1152.
Negative_regulation (blocked) of Phosphorylation (Phosphorylation) of MARCKS associated with agonist
2) Confidence 0.11 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.20 Pain Relevance 0.44

General Comments

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