INT130440

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Context Info
Confidence 0.79
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 7
Disease Relevance 2.93
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIN2B) plasma membrane (GRIN2B)
Anatomy Link Frequency
urethra 4
neuronal 1
external 1
GRIN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 1 100.00 Very High Very High Very High
Spinal cord 7 99.20 Very High Very High Very High
Neuropathic pain 1 98.92 Very High Very High Very High
intrathecal 6 98.40 Very High Very High Very High
Pain 7 96.08 Very High Very High Very High
referred pain 6 94.64 High High
Dorsal horn 6 91.36 High High
Inflammation 1 91.12 High High
agonist 3 74.24 Quite High
nMDA receptor antagonist 1 57.92 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 98.92 Very High Very High Very High
Stress Incontinence 30 98.78 Very High Very High Very High
Low Back Pain 6 96.36 Very High Very High Very High
Referred Pain 6 94.64 High High
Pain 1 93.24 High High
INFLAMMATION 1 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently demonstrated that continuous production of nitric oxide (NO) by neuronal NO synthase (nNOS) following phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and NMDA receptor NR2B subunits is essential for neuropathic pain.
Phosphorylation (phosphorylation) of NR2B in neuronal associated with nmda receptor and neuropathic pain
1) Confidence 0.79 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.28 Pain Relevance 0.43
Intrathecal immunoglobulin fusion protein of EphB1 and EphB2 as well as PP2 reversed the reflex sensitization and NR2B phosphorylation caused by MO.
Phosphorylation (phosphorylation) of NR2B associated with intrathecal
2) Confidence 0.15 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.39 Pain Relevance 0.28
All these results suggest that EphBR-ephrinB interactions, which provoke Src-family kinase-dependent NMDAR NR2B phosphorylation at the lumbosacral spinal cord level, are involved in cross-organ sensitization, contributing to the development of viscero-visceral referred pain between the bowel and the urethra.
Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence, referred pain and spinal cord
3) Confidence 0.15 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.55 Pain Relevance 0.29
Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B.
Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence
4) Confidence 0.15 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Title Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.19
We found MO instillation produced colon-urethra reflex sensitization along with an upregulation of endogenous ephrinB2 expression as well as phosphorylation of EphB 1/2, Src-family kinase, and NR2B tyrosine residues.
Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence
5) Confidence 0.11 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.42 Pain Relevance 0.27
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of NR2B in external associated with stress incontinence and dorsal horn
6) Confidence 0.10 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence and dorsal horn
7) Confidence 0.03 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17

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