INT130441

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.24
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (MARCKS) plasma membrane (MARCKS) cytoplasm (MARCKS)
Anatomy Link Frequency
neuronal 2
neurons 2
MARCKS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 263 100.00 Very High Very High Very High
nMDA receptor 7 99.76 Very High Very High Very High
Neuropathic pain 3 97.96 Very High Very High Very High
agonist 9 97.88 Very High Very High Very High
cocaine 41 97.14 Very High Very High Very High
nMDA receptor antagonist 3 96.60 Very High Very High Very High
long-term potentiation 4 96.16 Very High Very High Very High
Pain 3 93.24 High High
Inflammation 15 91.12 High High
Spinal cord 3 85.52 High High
Disease Link Frequency Relevance Heat
Virus Diseases 356 98.02 Very High Very High Very High
Neuropathic Pain 3 97.96 Very High Very High Very High
Pain 3 93.24 High High
Infection 118 92.64 High High
INFLAMMATION 15 91.12 High High
Cocaine Dependence 3 86.80 High High
Borna Disease 16 75.00 Quite High
Adhesions 1 74.12 Quite High
Respiratory Syncytial Virus 4 72.64 Quite High
Pressure And Volume Under Development 1 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Phosphorylation (phosphorylation) of MARCKS in neurons associated with kinase c
1) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
Indeed, phosphorylation of MARCKS by PKC is implicated in actin-dependent cytoskeletal plasticity [44] and in the maintenance of long-term potentiation in vivo [45].
Phosphorylation (phosphorylation) of MARCKS associated with kinase c and long-term potentiation
2) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.35 Pain Relevance 0.22
To determine the impact of the destruction of the PKC phosphorylation sites on BDV P, we directly stimulated the PKC pathway of neurons using the phorbol ester PMA and analyzed the phosphorylation status of two major PKC targets in neurons, myristoylated alanine-rich C kinase substrate (MARCKS) and synaptosomal-associated protein of 25 kDa (SNAP25) [32],[33].
Phosphorylation (phosphorylation) of MARCKS in neurons associated with virus diseases and kinase c
3) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.34 Pain Relevance 0.31
We used: mouse monoclonal antibodies to SNAP25 (Synaptic Systems, Goettingen, Germany), ß-tubulin (Sigma-Aldrich, Lyon, France), rabbit polyclonals to phospho-MARCKS (Ser152/156, a site specifically phosphorylated by PKC; Cell Signaling Technology, Danvers, Massachusetts, USA), MARCKS (Chemicon-Millipore, Saint-Quentin-en-Yvelines, France).
Phosphorylation (phosphorylated) of MARCKS associated with kinase c
4) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.54 Pain Relevance 0.20
We recently demonstrated that continuous production of nitric oxide (NO) by neuronal NO synthase (nNOS) following phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and NMDA receptor NR2B subunits is essential for neuropathic pain.
Phosphorylation (phosphorylation) of C-kinase substrate in neuronal associated with nmda receptor and neuropathic pain
5) Confidence 0.21 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.28 Pain Relevance 0.42
Phosphorylation of MARCKS and NADPH-diaphorase activity stimulated by the EP3 agonist were also blocked by H-1152.
Phosphorylation (Phosphorylation) of MARCKS associated with agonist
6) Confidence 0.21 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.20 Pain Relevance 0.44
We recently demonstrated that continuous production of nitric oxide (NO) by neuronal NO synthase (nNOS) following phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) and NMDA receptor NR2B subunits is essential for neuropathic pain.
Phosphorylation (phosphorylation) of MARCKS in neuronal associated with nmda receptor and neuropathic pain
7) Confidence 0.21 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.28 Pain Relevance 0.42
Cocaine activates mitogen activated protein kinase (MAPK), protein kinase C (PKC), and MLC kinase pathways in BMVEC’s as shown by an increase in ERK, MARCKS, and MLC phosphorylation, respectively.
Phosphorylation (phosphorylation) of MARCKS associated with kinase c and cocaine
8) Confidence 0.16 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.41 Pain Relevance 0.59

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