INT130444

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (MARCKS) plasma membrane (MARCKS) cytoplasm (MARCKS)
MARCKS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 99.52 Very High Very High Very High
Kinase C 3 98.94 Very High Very High Very High
cocaine 41 97.48 Very High Very High Very High
nMDA receptor antagonist 1 95.84 Very High Very High Very High
Spinal cord 1 84.76 Quite High
Neuropathic pain 1 75.56 Quite High
nMDA receptor 1 73.64 Quite High
Pain 1 63.24 Quite High
Inflammation 1 61.12 Quite High
Morphine 1 31.04 Quite Low
Disease Link Frequency Relevance Heat
Cocaine Dependence 3 87.48 High High
Neuropathic Pain 1 75.56 Quite High
Adhesions 1 74.80 Quite High
Pressure And Volume Under Development 1 73.12 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 24 66.80 Quite High
Pain 1 63.24 Quite High
INFLAMMATION 1 61.12 Quite High
Dementia 13 56.08 Quite High
Motor Neuron Diseases 5 53.48 Quite High
Drug Induced Neurotoxicity 1 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cocaine activates mitogen activated protein kinase (MAPK), protein kinase C (PKC), and MLC kinase pathways in BMVEC’s as shown by an increase in ERK, MARCKS, and MLC phosphorylation, respectively.
Positive_regulation (increase) of MARCKS associated with kinase c and cocaine
1) Confidence 0.12 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.41 Pain Relevance 0.58
Phosphorylation of MARCKS and NADPH-diaphorase activity stimulated by the EP3 agonist were also blocked by H-1152.
Positive_regulation (stimulated) of MARCKS associated with agonist
2) Confidence 0.12 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16188227 Disease Relevance 0.20 Pain Relevance 0.44

General Comments

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