INT130472

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.40
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal 2
spinal cord 2
body 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 71 100.00 Very High Very High Very High
antagonist 7 99.98 Very High Very High Very High
Morphine 14 99.84 Very High Very High Very High
Eae 32 99.64 Very High Very High Very High
withdrawal 14 99.12 Very High Very High Very High
Inflammation 28 98.84 Very High Very High Very High
allodynia 22 97.38 Very High Very High Very High
intrathecal 8 97.36 Very High Very High Very High
agonist 1 96.64 Very High Very High Very High
Pain 119 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 134 100.00 Very High Very High Very High
Inflammatory Pain 18 99.64 Very High Very High Very High
Cancer 76 99.30 Very High Very High Very High
INFLAMMATION 32 98.84 Very High Very High Very High
Neuropathic Pain 82 97.38 Very High Very High Very High
Pain 125 96.44 Very High Very High Very High
Pancreatic Cancer 17 88.40 High High
Morphine Dependence 2 87.28 High High
Skin Cancer 8 77.28 Quite High
Injury 10 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin, an inhibitor of prostaglandin (PG) synthesis, and PGE receptor subtype EP1-selective antagonist reduced the NR2B phosphorylation in these mice.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of NR2B associated with antagonist
1) Confidence 0.40 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.65 Pain Relevance 1.20
production in cancer-inoculated regions, which in turn inhibits ephrin B1 gene expression, and tyrosine phosphorylation of NR2B.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of NR2B associated with cancer
2) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.72 Pain Relevance 1.14
NR2B phosphorylation in spinal cord of ephrin-B2 CKO mutants is lost in some inflammatory pain models
Negative_regulation (lost) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with targeted disruption, eae and spinal cord
3) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.92 Pain Relevance 0.81
Further, spinal administration of exogenous MMP-9 induces morphine withdrawal-like behavioral signs and mechanical allodynia, activates NR1 and NR2 receptors, and downregulates integrin-beta1, while a function-neutralizing antibody against integrin-beta1 suppresses MMP-9-induced phosphorylation of NR1 and NR2B.
Negative_regulation (suppresses) of Phosphorylation (phosphorylation) of NR2B in spinal associated with allodynia, withdrawal and morphine
4) Confidence 0.26 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.45 Pain Relevance 1.67
Slack et al. also demonstrated that intrathecal infusion of ephrin-B2 in adult rats induces NR2B phophorylation, probably via src family kinases, and EphB1 receptor body infusion prevents NR2B phophorylation in the carrageenan model of inflammation [32].
Negative_regulation (prevents) of Phosphorylation (phophorylation) of NR2B in body associated with inflammation and intrathecal
5) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.65 Pain Relevance 0.95

General Comments

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