INT130475

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 11.52
Pain Relevance 10.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 8
dorsal horn 4
spinal 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 165 100.00 Very High Very High Very High
Dorsal horn 89 100.00 Very High Very High Very High
nMDA receptor 55 100.00 Very High Very High Very High
withdrawal 26 99.98 Very High Very High Very High
Neuropathic pain 121 99.90 Very High Very High Very High
Pain 469 99.60 Very High Very High Very High
Morphine 24 99.50 Very High Very High Very High
antagonist 29 99.08 Very High Very High Very High
Eae 64 95.52 Very High Very High Very High
Cholecystokinin 15 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 190 99.90 Very High Very High Very High
Pancreatic Cancer 85 99.72 Very High Very High Very High
Cancer 380 99.68 Very High Very High Very High
Pain 490 99.08 Very High Very High Very High
Nervous System Injury 19 99.08 Very High Very High Very High
Targeted Disruption 268 98.76 Very High Very High Very High
Inflammatory Pain 36 95.52 Very High Very High Very High
INFLAMMATION 100 90.16 High High
Skin Cancer 40 82.72 Quite High
Drug Dependence 2 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
Positive_regulation (essential) of Phosphorylation (phosphorylation) of NR2B associated with pain, nmda receptor and neuropathic pain
1) Confidence 0.47 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16190898 Disease Relevance 0.71 Pain Relevance 1.32
Neuropathic pain and NR2B phosphorylation at Tyr1472 were attenuated by the NR2B-selective antagonist CP-101,606 and disappeared in mice lacking Fyn kinase, a Src-family tyrosine kinase.
Positive_regulation (attenuated) of Phosphorylation (phosphorylation) of NR2B associated with antagonist and neuropathic pain
2) Confidence 0.47 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.76 Pain Relevance 1.12
However, there was no significant increase of NR2B phosphorylation in dorsal horn from the Efnb2 CKO mutant mice (93.1 ± 20.7%) (Additional file 1, S4A).
Neg (no) Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with targeted disruption and dorsal horn
3) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.64 Pain Relevance 0.41
In a mouse model of cancer-induced pain, ephrin B1 gene expression in dorsal root ganglia (DRGs) and the phosphorylation of NR2B in the spinal cord were induced.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
4) Confidence 0.41 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.16 Pain Relevance 0.94
We also found that the tyrosine phosphorylation of NR2B in the spinal cord was enhanced in the cancer-induced pain model in mice.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
5) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 2.20 Pain Relevance 1.46
from a cancer-inoculated region, induction of ephrin B1 gene expression in DRGs, and subsequent enhancement of tyrosine phosphorylation of NR2B in the spinal cord.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with cancer and spinal cord
6) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.55 Pain Relevance 1.31
Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 ?
Positive_regulation (regulation) of Phosphorylation (phosphorylation) of NR2B associated with pancreatic cancer
7) Confidence 0.41 Published 2010 Journal Mol Pain Section Title Doc Link PMC2987997 Disease Relevance 0.95 Pain Relevance 0.76
As it has been reported that ephrin B2 induces phosphorylation of Tyr-1472 residues [14], we next investigated whether Tyr-1472 phosphorylation of NR2B was enhanced in the spinal cord of the mouse model of cancer-induced pain.
Spec (whether) Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
8) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.06 Pain Relevance 0.66
The result shows that the relative level of phosphorylated NR2B in dorsal horn from the Efnb2fl/fl control mice was remarkably increased (184.2 ± 17.1%) after formalin injection.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of NR2B in dorsal horn associated with dorsal horn
9) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.70 Pain Relevance 0.53
Morphine exposure and withdrawal increase phosphorylation of NR1 and NR2B receptors, ERK1/2, calmodulin-dependent kinase II, and cAMP response element binding proteins; and such phosphorylation is suppressed by either spinal inhibition or targeted mutation of MMP-9.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of NR2B in spinal associated with withdrawal and morphine
10) Confidence 0.31 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.30 Pain Relevance 1.32
Immunoprecipitation (IP) and Western blot of NR2B was performed to establish whether formalin treatment induces tyrosine phosphorylation of NMDA receptor subunit NR2B, and if the extent of the phosphorylation is different in Efnb2 CKO mutant mice and Efnb2fl/fl controls.
Spec (whether) Positive_regulation (induces) of Phosphorylation (phosphorylation) of NR2B associated with targeted disruption and nmda receptor
11) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.82 Pain Relevance 0.75
The relative level of phosphorylated NR2B was significantly increased in Efnb2fl/fl controls (138.4 ± 13.8%) 24 hours after CFA injection, but not in Efnb2 CKO mice (108.3 ± 13.0%) (Additional file 1, S4B).


Positive_regulation (increased) of Phosphorylation (phosphorylated) of NR2B associated with targeted disruption
12) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.65 Pain Relevance 0.39

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