INT130476

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.99
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Fyn) mitochondrion (Fyn) plasma membrane (Fyn)
kinase activity (Fyn)
Anatomy Link Frequency
mast cells 2
growth cones 1
Fyn (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 100.00 Very High Very High Very High
nMDA receptor 8 99.84 Very High Very High Very High
Spinal cord 8 98.16 Very High Very High Very High
Neuropathic pain 16 97.04 Very High Very High Very High
agonist 2 95.20 Very High Very High Very High
antagonist 5 91.92 High High
Dorsal horn 7 79.16 Quite High
Neuronal nitric oxide synthase 2 76.96 Quite High
dorsal root ganglion 148 64.48 Quite High
nociceptor 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1 99.08 Very High Very High Very High
Shock 88 98.80 Very High Very High Very High
Neuropathic Pain 16 97.04 Very High Very High Very High
Pain 7 91.64 High High
Obesity 22 87.20 High High
Apoptosis 18 84.12 Quite High
Endotoxemia 1 81.72 Quite High
Nociception 1 75.00 Quite High
Nervous System Injury 2 72.28 Quite High
Ganglion Cysts 152 64.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reeler gene encodes Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1).
Phosphorylation (phosphorylation) of Fyn associated with disorder of lipid metabolism
1) Confidence 0.80 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279306 Disease Relevance 0.17 Pain Relevance 0.04
The present study demonstrates that Tyr1472 phosphorylation of NR2B subunits by Fyn kinase may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase, and suggests that PGE2 is involved in the maintenance of neuropathic pain via the EP1 subtype.
Phosphorylation (phosphorylation) of Fyn associated with nmda receptor and neuropathic pain
2) Confidence 0.54 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.63 Pain Relevance 1.05
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
Phosphorylation (phosphorylation) of Fyn associated with pain, nmda receptor and neuropathic pain
3) Confidence 0.42 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16190898 Disease Relevance 0.69 Pain Relevance 1.29
Fyn was also shown to phosphorylate Cdk5 and the PlexinA2 cytoplasmic domain [44].
Phosphorylation (phosphorylate) of Fyn
4) Confidence 0.38 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.28 Pain Relevance 0.03
There is also evidence that Fyn might regulate Fps, and possibly Fer, as Fyn has been shown to phosphorylate a kinase-defective mutant form of Fps in Sf-9 cells [45], Fer and Fyn cooperate in actin depolymerization-induced cortactin phosphorylation [26], and the Fyn-related Lyn kinase regulates Fer phosphorylation in mast cells downstream of the IgE receptor engagement [46].
Phosphorylation (phosphorylation) of Fyn in mast cells
5) Confidence 0.38 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.14 Pain Relevance 0
Sema3A induced the phosphorylation and activation of Cdk5 by Fyn, which was essential for the collapse of sensory growth cones by Sema3A.
Phosphorylation (phosphorylation) of Fyn in growth cones associated with shock
6) Confidence 0.30 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.28 Pain Relevance 0.03
There is also evidence that Fyn might regulate Fps, and possibly Fer, as Fyn has been shown to phosphorylate a kinase-defective mutant form of Fps in Sf-9 cells [45], Fer and Fyn cooperate in actin depolymerization-induced cortactin phosphorylation [26], and the Fyn-related Lyn kinase regulates Fer phosphorylation in mast cells downstream of the IgE receptor engagement [46].
Phosphorylation (phosphorylate) of Fyn in mast cells
7) Confidence 0.30 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.15 Pain Relevance 0
Following a leptin stimulus, Fyn undergoes an activating tyrosine phosphorylation and a transient association with IRS1 [54].
Phosphorylation (phosphorylation) of Fyn
8) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.64 Pain Relevance 0

General Comments

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